The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …

Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Gene editing using engineered nucleases frequently produces unintended genetic lesions
in hematopoietic stem cells (HSCs). Gene-edited HSC cultures thus contain heterogeneous …

Mutation accumulation in stem cells has been associated with cancer risk. However, the
presence of numerous mutant clones in healthy tissues has raised the question of what …

Biliary epithelial cells (BECs) are a potential source to repair the damaged liver when
hepatocyte proliferation is compromised. Promotion of BEC-to-hepatocyte …

Introduction In haematopoietic stem cell transplantation (HSCT), haematopoietic stem cells
(HSCs) from a healthy donor replace the patient's ones. Ex vivo HSC gene therapy (HSC …

The bone marrow supports and regulates hematopoiesis, responding to physiological
requirements for blood cell production over ontogeny and during pathological challenges …

Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic
waves that generate the differentiated blood cells required for embryonic development while …

The haematopoietic system plays an essential role in our health and survival. It is comprised
of a range of mature blood and immune cell types, including oxygen-carrying erythrocytes …

Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of
somatic stem cells for gene and cell therapies. CB and UC can be obtained noninvasively …