[HTML][HTML] Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
[HTML][HTML] Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Q Lu, D Kou, S Lou, M Ashrafizadeh, AR Aref… - Journal of Hematology & …, 2024 - Springer
Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …
against cancers. Despite these advancements, challenges remain, particularly in the clinical …
Interferon-ε is a tumour suppressor and restricts ovarian cancer
High-grade serous ovarian cancers have low survival rates because of their late
presentation with extensive peritoneal metastases and frequent chemoresistance, and …
presentation with extensive peritoneal metastases and frequent chemoresistance, and …
Oncogenic drivers and therapeutic vulnerabilities in KRAS wild-type pancreatic cancer
Abstract Purpose: Approximately 8% to 10% of pancreatic ductal adenocarcinomas (PDAC)
do not harbor mutations in KRAS. Understanding the unique molecular and clinical features …
do not harbor mutations in KRAS. Understanding the unique molecular and clinical features …
[HTML][HTML] Nivolumab and ipilimumab in recurrent or refractory cancer of unknown primary: a phase II trial
M Pouyiourou, BN Kraft, T Wohlfromm, M Stahl… - Nature …, 2023 - nature.com
Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-
based chemotherapy. 10-20% of patients have a high tumor mutational burden (TMB), which …
based chemotherapy. 10-20% of patients have a high tumor mutational burden (TMB), which …
Late-stage metastatic melanoma emerges through a diversity of evolutionary pathways
Understanding the evolutionary pathways to metastasis and resistance to immune-
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …
Nivolumab for patients with high-risk oral leukoplakia: A nonrandomized controlled trial
Importance Proliferative verrucous leukoplakia (PVL) is an aggressive oral precancerous
disease characterized by a high risk of transformation to invasive oral squamous cell …
disease characterized by a high risk of transformation to invasive oral squamous cell …
Chromosomal instability as a driver of cancer progression
X Chen, AS Agustinus, J Li, M DiBona… - Nature Reviews …, 2024 - nature.com
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
Aneuploidy in human cancer: new tools and perspectives
Chromosome copy number imbalances, otherwise known as aneuploidies, are a common
but poorly understood feature of cancer. Here, we describe recent advances in both …
but poorly understood feature of cancer. Here, we describe recent advances in both …
Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer
T Huth, EC Dreher, S Lemke, S Fritzsche… - Science …, 2023 - science.org
Large-scale chromosomal aberrations are prevalent in human cancer, but their function
remains poorly understood. We established chromosome-engineered hepatocellular …
remains poorly understood. We established chromosome-engineered hepatocellular …