A key property of complex biological systems is the presence of interaction networks formed
by its different components, primarily proteins. These are crucial for all levels of cellular …

Mitochondrial creatine kinase (MtCK), together with cytosolic creatine kinase isoenzymes
and the highly diffusible CK reaction product, phosphocreatine, provide a temporal and …

There is much recent evidence showing that mitochondria play a critical role in the
regulation of apoptosis (programmed cell death), making them an attractive target for the …

Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These
components also play important roles in cell homeostasis by regulating cell function and …

Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal
physiological conditions, ROS production is tightly regulated, and ROS participate in both …

Diabetic neuropathy is the most common and debilitating complication of diabetes mellitus
with more than half of all patients developing altered sensation as a result of damage to …

Stroke is one of the leading causes of death and disability worldwide. Brain injury after
ischemic stroke involves multiple pathophysiological mechanisms, such as oxidative stress …

Mitochondria are essential for maintaining cell life but they also play a role in regulating cell
death, which occurs when their membranes become permeabilized. Mitochondria possess …

Differentiation and dedifferentiation of vascular smooth muscle cells (VSMCs) are essential
processes of vascular development. VSMC have biosynthetic, proliferative, and contractile …

The family Trypanosomatidae, flagellated parasitic protozoa, is responsible for important
infectious diseases in humans: sleeping sickness, Chagas diseases and leishmaniasis …