The extracellular matrix (ECM) is a complex network composed of a multitude of different
macromolecules. ECM components typically provide a supportive structure to the tissue and …

Fixed-drug combinations have been used for the treatment of cancer. Current anticancer
therapies, however, tend to induce resistance and provoke important toxicity. Therefore …

Although drug combinations in cancer treatment appear to be a promising therapeutic
strategy with respect to monotherapy, it is arduous to discover new synergistic drug …

The combination of folinic acid, 5-fluorouracil, oxaliplatin and/or irinotecan (FOLFOXIRI) is
the standard of care for metastatic colorectal cancer (CRC). This strategy inhibits tumor …

The epithelial-mesenchymal transition (EMT) is an important process during metastasis in
various tumors, including colorectal cancer (CRC). Thus, the study of its characteristics and …

Simple Summary To ameliorate the situation for kidney cancer patients and to broaden the
application of available drugs, we initiated this research to enhance the anti-cancer activity …

Colorectal cancer (CRC) represents one of the most widespread forms of cancer in the
population and, as all malignant tumors, often develops resistance to chemotherapies with …

The development of successful treatment regimens for breast cancer requires strong pre-
clinical data generated in physiologically relevant pre-clinical models. Here we report the …

Purpose Colon cancer presents challenges to clinical diagnosis and management due to its
high heterogeneity. For more efficient and convenient diagnosis and treatment of colon …

A major limitation of clinically used cancer drugs is the lack of specificity resulting in toxicity.
To address this, we performed a phenotypically-driven screen to identify optimal multidrug …