The crucial role of ZEB2: from development to epithelial‐to‐mesenchymal transition and cancer complexity

M Fardi, M Alivand, B Baradaran… - Journal of cellular …, 2019 - Wiley Online Library
Zinc finger E‐box binding homeobox 2 (ZEB2) is a DNA‐binding transcription factor, which
is mainly involved in epithelial‐to‐mesenchymal transition (EMT). EMT is a conserved …

[HTML][HTML] TMPRSS4 promotes cancer stem–like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1

Y Lee, J Yoon, D Ko, M Yu, S Lee, S Kim - Journal of Experimental & …, 2021 - Springer
Background Transmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored
serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in …

[HTML][HTML] Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

MM Gladka, A Kohela, B Molenaar, D Versteeg… - Nature …, 2021 - nature.com
The disruption in blood supply due to myocardial infarction is a critical determinant for infarct
size and subsequent deterioration in function. The identification of factors that enhance …

[HTML][HTML] TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer

S Kim - Experimental & Molecular Medicine, 2023 - nature.com
Proteases are involved in almost all biological processes, implying their importance for both
health and pathological conditions. Dysregulation of proteases is a key event in cancer …

Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis

A Ding, CH Li, CY Yu, HT Zhou, ZH Zhang - Laboratory Investigation, 2021 - nature.com
Bone regeneration is a coordinated process involving connections between blood vessels
and osteocytes. Angiogenesis and osteogenesis are tightly connected throughout the …

[HTML][HTML] Anti-cancer activity of the novel 2-hydroxydiarylamide derivatives IMD-0354 and KRT1853 through suppression of cancer cell invasion, proliferation, and …

S Kim, D Ko, Y Lee, S Jang, Y Lee, IY Lee, S Kim - Scientific Reports, 2019 - nature.com
Elevated expression of transmembrane serine protease 4 (TMPRSS4) correlates with poor
prognosis in non-small cell lung cancer, gastric cancer, colorectal cancer, prostate cancer …

[HTML][HTML] Epithelial-to-mesenchymal transition and neoangiogenesis in laryngeal squamous cell carcinoma

L Franz, L Nicolè, AC Frigo, G Ottaviano, P Gaudioso… - Cancers, 2021 - mdpi.com
Simple summary The mechanism of epithelial–mesenchymal transition is fundamental for
carcinogenesis, tumor progression, cancer cell invasion, metastasis, recurrence, and …

[HTML][HTML] TMEM52B suppression promotes cancer cell survival and invasion through modulating E-cadherin stability and EGFR activity

Y Lee, D Ko, J Yoon, Y Lee, S Kim - Journal of Experimental & Clinical …, 2021 - Springer
Background TMEM52B is a novel gene broadly expressed in a variety of normal human
tissues. However, the biological function of TMEM52B expression in cancer is largely …

An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer‐Associated Angiogenesis Studies

HS Rahman, BL Tan, HH Othman… - BioMed Research …, 2020 - Wiley Online Library
Angiogenesis is a crucial area in scientific research because it involves many important
physiological and pathological processes. Indeed, angiogenesis is critical for normal …

[HTML][HTML] Prognostic value of survivin in nasopharyngeal carcinoma: A systematic review and meta-analysis

W Xie, O Yan, F Liu, Y Han, H Wang - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
Background: Previous studies have shown that survivin has potential prognostic value in
nasopharyngeal carcinoma. However, the results remained controversial until now. Thus, to …