Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …

In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

Most human cells require anchorage for survival. Cell–substrate adhesion activates diverse
signalling pathways, without which cells undergo anoikis—a form of programmed cell death …

Septins are a conserved family of GTP-binding proteins that assemble into symmetric linear
heterooligomeric complexes, which in turn are able to polymerize into apolar filaments and …

Septins are conserved GTP-binding proteins that assemble into hetero-oligomeric
complexes and higher-order structures such as filaments, rings, hourglasses or gauzes …

Human septins comprise a family of 13 genes that encode for> 30 protein isoforms with
ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble …

The actin and microtubule cytoskeletons comprise a variety of networks with distinct
architectures, dynamics and protein composition. A fundamental question in eukaryotic cell …

Septins are conserved GTP-binding proteins that assemble into lateral diffusion barriers and
molecular scaffolds. Vertebrate genomes contain 9–17 septin genes that encode both …