Molecular profile and FDG-PET/CT total metabolic tumor volume improve risk classification at diagnosis for patients with diffuse large B-cell lymphoma
AS Cottereau, H Lanic, S Mareschal, M Meignan… - Clinical Cancer …, 2016 - AACR
Purpose: The prognostic impact of total metabolic tumor volume (TMTV) measured on
pretreatment 18F-FDG PET/CT and its added value to molecular characteristics was …
pretreatment 18F-FDG PET/CT and its added value to molecular characteristics was …
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo
L Fontan, C Yang, V Kabaleeswaran, L Volpon… - Cancer cell, 2012 - cell.com
MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B
cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. We developed a MALT1 …
cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. We developed a MALT1 …
Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
The aims of this study were to assess the feasibility of prospective pharmacogenomics
research in multicenter international clinical trials of bortezomib in multiple myeloma and to …
research in multicenter international clinical trials of bortezomib in multiple myeloma and to …
Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
D Dornan, F Bennett, Y Chen, M Dennis… - Blood, The Journal …, 2009 - ashpublications.org
Here we describe the generation of an antibody–drug conjugate (ADC) consisting of a
humanized anti-CD79b antibody that is conjugated to monomethylauristatin E (MMAE) …
humanized anti-CD79b antibody that is conjugated to monomethylauristatin E (MMAE) …
Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma
Fifty percent of diffuse large B cell lymphoma (DLBCL) cases lack cell-surface expression of
the class I major histocompatibility complex (MHC-I), thus escaping recognition by cytotoxic …
the class I major histocompatibility complex (MHC-I), thus escaping recognition by cytotoxic …
A phase 2/3 multicenter, randomized, open-label study to compare the efficacy and safety of lenalidomide versus investigator's choice in patients with relapsed or …
MS Czuczman, M Trněný, A Davies, S Rule… - Clinical cancer …, 2017 - AACR
Abstract Purpose: Randomized, multicenter, open-label, phase 2/3 trial investigating
lenalidomide versus investigator's choice (IC) in relapsed/refractory diffuse large B-cell …
lenalidomide versus investigator's choice (IC) in relapsed/refractory diffuse large B-cell …
Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens
The activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) relies on
chronic active B-cell receptor (BCR) signaling. BCR pathway inhibitors induce remissions in …
chronic active B-cell receptor (BCR) signaling. BCR pathway inhibitors induce remissions in …
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
Proteolytic activity of the mucosa-associated lymphoid tissue lymphoma translocation
protein-1 (MALT1) paracaspase is required for survival of the activated B cell subtype of …
protein-1 (MALT1) paracaspase is required for survival of the activated B cell subtype of …
Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma
R Shen, D Fu, L Dong, MC Zhang, Q Shi… - … and Targeted Therapy, 2023 - nature.com
Genetic classification helps to disclose molecular heterogeneity and therapeutic implications
in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA …
in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA …
Approach to the diagnosis and treatment of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements
P Sesques, NA Johnson - Blood, The Journal of the American …, 2017 - ashpublications.org
High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements,
so-called “double-hit” lymphomas (HGBL-DH), are aggressive lymphomas that form a …
so-called “double-hit” lymphomas (HGBL-DH), are aggressive lymphomas that form a …