Understanding intraocular lymphomas

SE Coupland, B Damato - Clinical & experimental …, 2008 - Wiley Online Library
The purpose of this review is to describe the clinical features, pathology and molecular
biology of intraocular lymphomas, which represent a heterogenous group of malignant …

BCL2 Expression Is a Prognostic Marker for the Activated B-Cell–Like Type of Diffuse Large B-Cell Lymphoma

J Iqbal, VT Neppalli, G Wright, BJ Dave… - Journal of Clinical …, 2006 - ascopubs.org
Background The role of BCL2 as a predictor of survival in diffuse large B-cell lymphoma
(DLBCL) is controversial. DLBCL is heterogeneous, and the expression of BCL2 is variable …

WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects

G Burg, W Kempf, A Cozzio, J Feit… - Journal of cutaneous …, 2005 - Wiley Online Library
The new WHO/EORTC classification for cutaneous lymphomas comprises mature T‐cell and
natural killer (NK)‐cell neoplasms, mature B‐cell neoplasms, and immature hematopoietic …

Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma

JL Rubenstein, J Fridlyand, L Abrey, A Shen… - Journal of clinical …, 2007 - ascopubs.org
Purpose We previously determined that intravenous administration of rituximab results in
limited penetration of this agent into the leptomeningeal space. Systemic rituximab does not …

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas

BB Ding, JJ Yu, RYL Yu, LM Mendez… - Blood, The Journal …, 2008 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) consists of at least 2 phenotypic subtypes; that is,
the germinal center B-cell–like (GCB-DLBCL) and the activated B-cell–like (ABC-DLBCL) …

BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma

J Iqbal, WG Sanger, DE Horsman, A Rosenwald… - The American journal of …, 2004 - Elsevier
Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed
prognostically important subgroups: germinal center B-cell-like (GCB) DLBCL, activated B …

Small molecule inhibitors of IκB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling

LT Lam, RE Davis, J Pierce, M Hepperle, Y Xu… - Clinical cancer …, 2005 - AACR
Constitutive activation of the NF-κB pathway is required for survival of the activated B cell–
like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL). Here we show that a small …

Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies

W Du, O Elemento - Oncogene, 2015 - nature.com
The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Lenalidomide plus R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma: results of the REAL07 open-label, multicentre, phase 2 trial

U Vitolo, A Chiappella, S Franceschetti… - The Lancet …, 2014 - thelancet.com
Background Up to 40% of elderly patients with untreated diffuse large B-cell lymphoma
(DLBCL) given a regimen of rituximab, cyclophosphamide, doxorubicin, vincristine, and …

[HTML][HTML] Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma

SM Aukema, M Kreuz, CW Kohler, M Rosolowski… - …, 2014 - ncbi.nlm.nih.gov
Chromosomal translocations affecting the MYC oncogene are the biological hallmark of
Burkitt lymphomas but also occur in a subset of other mature B-cell lymphomas. If …