Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches
M Sekhoacha, K Riet, P Motloung, L Gumenku… - Molecules, 2022 - mdpi.com
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …
higher rates of mortality in those belonging to a lower socioeconomic status due to late …
[HTML][HTML] Cytochrome P450: polymorphisms and roles in cancer, diabetes and atherosclerosis
Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …
metabolism of drugs and other substances. Endogenous substrates of CYPs include …
Summary of information on human CYP enzymes: human P450 metabolism data
S Rendic - Drug metabolism reviews, 2002 - Taylor & Francis
This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …
Inhibition and induction of human cytochrome P450 enzymes: current status
Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …
Cytochrome P450 pharmacogenetics and cancer
C Rodriguez-Antona, M Ingelman-Sundberg - Oncogene, 2006 - nature.com
The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …
They mediate the metabolic activation of numerous precarcinogens and participate in the …
Understanding and targeting resistance mechanisms in cancer
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …
practice, which is one of the major causes of treatment failure and poor patient survival. The …
Acetylene group, friend or foe in medicinal chemistry
TT Talele - Journal of Medicinal Chemistry, 2020 - ACS Publications
The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …
Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …
Potential role of CYP1B1 in the development and treatment of metabolic diseases
F Li, W Zhu, FJ Gonzalez - Pharmacology & therapeutics, 2017 - Elsevier
Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update
SP Rendic, FP Guengerich - Archives of toxicology, 2021 - Springer
This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …