Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

The cytochromes P450 (CYPs) are key enzymes in cancer formation and cancer treatment.
They mediate the metabolic activation of numerous precarcinogens and participate in the …

Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of
the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been …

Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …

Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …