New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

YI Duan, C Llorente, S Lang, K Brandl, H Chu… - Nature, 2019 - nature.com
Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …

Proteases involved in leader peptide removal during RiPP biosynthesis

SM Eslami, WA van der Donk - ACS Bio & Med Chem Au, 2023 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) have received
much attention in recent years because of their promising bioactivities and the portability of …

Probiotic Potential and Safety Evaluation of Enterococcus faecalis OB14 and OB15, Isolated From Traditional Tunisian Testouri Cheese and Rigouta, Using …

O Baccouri, AM Boukerb, LB Farhat, A Zébré… - Frontiers in …, 2019 - frontiersin.org
Lactic acid bacteria (LAB) strains OB14 and OB15 were isolated from traditional Tunisian
fermented dairy products, Testouri cheese and Rigouta, respectively. They were identified …

[PDF][PDF] LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

KY Lai, SRG Galan, Y Zeng, TH Zhou, C He, R Raj… - Cell, 2021 - cell.com
Enzyme-mediated damage repair or mitigation, while common for nucleic acids, is rare for
proteins. Examples of protein damage are elimination of phosphorylated Ser/Thr to …

Structural Analysis of Class I Lanthipeptides from Pedobacter lusitanus NL19 Reveals an Unusual Ring Pattern

IR Bothwell, T Caetano, R Sarksian, S Mendo… - ACS chemical …, 2021 - ACS Publications
Lanthipeptides are ribosomally synthesized and post-translationally modified peptide
natural products characterized by the presence of lanthionine and methyllanthionine cross …

[HTML][HTML] Maturation of subtilisin-like protease NbSLP1 from microsporidia Nosema bombycis

R Wang, Q Li, F Liu, X Dang, Q Sun… - Frontiers in Cellular …, 2022 - frontiersin.org
Microsporidia are obligate intracellular parasites and possess a unique way of invading
hosts, namely germination. Microsporidia are able to infect almost all animal cells by …

Structure–Activity Relationships of the Enterococcal Cytolysin

IR Rahman, A Sanchez, W Tang… - ACS infectious …, 2021 - ACS Publications
Enterococcal cytolysin is a hemolytic virulence factor linked to human disease and
increased patient mortality. Produced by pathogenic strains of Enterococcus faecalis …

Peptide backbone modifications in lanthipeptides

RS Ayikpoe, WA van der Donk - Methods in Enzymology, 2021 - Elsevier
Lanthipeptides are a class of ribosomally synthesized and posttranslationally modified
peptide (RiPP) natural products characterized by the presence of lanthionine and …

[HTML][HTML] Expression of Lanthipeptides in Human Cells

SM Eslami, IR Rahman, WA van der Donk - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cyclic peptides represent a burgeoning area of interest in therapeutic and biotechnological
research. In opposition to their linear counterparts, cyclic peptides, such as certain …