Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …

Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …

Background DNA methylation and the Polycomb repression system are epigenetic
mechanisms that play important roles in maintaining transcriptional repression. Recent …

Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …

Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …

Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …

During differentiation of embryonic stem cells, chromatin reorganizes to establish cell type-
specific expression programs. Here, we have dissected the linkages between DNA …

Upon retinal injury, zebrafish Müller glia (MG) transition from a quiescent supportive cell to a
progenitor cell (MGPC). This event is accompanied by the induction of key transcription and …

在真核生物中, DNA 甲基化是一种非常重要的表观遗传学标记, 能影响染色质的结构和基因的
表达. 随着全基因组甲基化测序的发展, 全基因组范围内的DNA 甲基化水平得以了解 …

The viability of any species requires that the genome is kept stable as it is transmitted from
generation to generation by the germ cells. One of the challenges to transgenerational …