[HTML][HTML] Natural Killer Cell Engagers (NKCEs): a new frontier in cancer immunotherapy
Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …
[HTML][HTML] The cell density effect in animal cell-based bioprocessing: Questions, insights and perspectives
J Lavado-García, P Pérez-Rubio, L Cervera… - Biotechnology …, 2022 - Elsevier
One of the main challenges in the development of bioprocesses based on cell transient
expression is the commonly reported reduction of cell specific productivity at increasing cell …
expression is the commonly reported reduction of cell specific productivity at increasing cell …
[HTML][HTML] The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of …
M Jang, ES Pete, P Bruheim - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Serum-free cultures are preferred for application in clinical cell therapy and facilitate the
purification processes of bioproducts, such as vaccines and recombinant proteins. It can …
purification processes of bioproducts, such as vaccines and recombinant proteins. It can …
[HTML][HTML] Inhibition of O-glcnacylation reduces cell viability and autophagy and increases sensitivity to chemotherapeutic temozolomide in glioblastoma
AV Leonel, F Alisson-Silva, RCM Santos… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma (GB) is the most common and aggressive type of malignant
brain tumor; however, despite advances in treatment modalities, it remains largely incurable …
brain tumor; however, despite advances in treatment modalities, it remains largely incurable …
[HTML][HTML] Inducible HEK293 AAV packaging cell lines expressing Rep proteins
L Jalšić, V Lytvyn, SM Elahi, S Hrapovic… - … Therapy-Methods & …, 2023 - cell.com
Packaging or producer cell lines for scalable recombinant adeno-associated virus (rAAV)
production have been notoriously difficult to create due in part to the cytostatic nature of the …
production have been notoriously difficult to create due in part to the cytostatic nature of the …
[HTML][HTML] Automated cell counting for Trypan blue-stained cell cultures using machine learning
L Kuijpers, E van Veen, LA van der Pol, NH Dekker - Plos one, 2023 - journals.plos.org
Cell counting is a vital practice in the maintenance and manipulation of cell cultures. It is a
crucial aspect of assessing cell viability and determining proliferation rates, which are …
crucial aspect of assessing cell viability and determining proliferation rates, which are …
CRISPR-COPIES: an in silico platform for discovery of neutral integration sites for CRISPR/Cas-facilitated gene integration
AG Boob, Z Zhu, P Intasian, M Jain… - Nucleic acids …, 2024 - academic.oup.com
The CRISPR/Cas system has emerged as a powerful tool for genome editing in metabolic
engineering and human gene therapy. However, locating the optimal site on the …
engineering and human gene therapy. However, locating the optimal site on the …
[HTML][HTML] Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard
Adeno-associated viruses (AAVs) are non-enveloped ssDNA icosahedral T= 1 viruses used
as vectors for clinical gene delivery. Currently, there are over 200 AAV-related clinical trials …
as vectors for clinical gene delivery. Currently, there are over 200 AAV-related clinical trials …
[HTML][HTML] Novel insights into the isolation of extracellular vesicles by anion exchange chromatography
LF Koch, T Best, E Wüstenhagen, K Adrian… - … in Bioengineering and …, 2024 - frontiersin.org
Extracellular vesicles (EVs) are membrane structures enclosed by a lipid bilayer that are
released into the extracellular space by all types of cells. EVs are involved in many …
released into the extracellular space by all types of cells. EVs are involved in many …
Enhanced cellular internalization of near-infrared fluorescent single-walled carbon nanotubes facilitated by a transfection reagent
N Levin, A Hendler-Neumark, D Kamber… - Journal of Colloid and …, 2024 - Elsevier
Functionalized single-walled carbon nanotubes (SWCNTs) hold immense potential for
diverse biomedical applications due to their biocompatibility and optical properties …
diverse biomedical applications due to their biocompatibility and optical properties …