Patient-derived tumor organoids (PDOs) are a highly promising preclinical model that
recapitulates the histology, gene expression, and drug response of the donor patient tumor …

The tumor microenvironment comprises multiple cell types, like cancer cells, endothelial
cells, fibroblasts, and immune cells. In recent years, there have been massive research …

Abstract Purpose of Review Lung fibrosis is currently thought to stem from an aberrant
wound healing response after recurring (micro) injuries in the lung epithelium, together with …

Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment
that induce deformations and remodeling of the fiber network. By measuring these …

The role of fibrillar collagen in the tissue microenvironment is critical in disease contexts
ranging from cancers to chronic inflammations, as evidenced by many studies. Quantifying …

Biomarkers are indispensable for precision medicine. However, focused single-biomarker
development using human tissue has been complicated by sample spatial heterogeneity. To …

Fibrillar collagens are the most abundant extracellular matrix components in non–small cell
lung cancer (NSCLC). However, the potential of collagen fiber descriptors as a source of …

Accurate and rapid diagnosis of breast cancer is particularly important since it becomes the
primary malignant tumor threatening women's health. Although pathological diagnosis with …

Healing wounds and cancers present remarkable cellular and molecular parallels, but the
specific roles of the healing phases are largely unknown. We developed a bioinformatics …

Despite careful staging, the accuracy for preoperative detection of small distant metastases
remains poor, creating a clinical need for enhanced operative staging to detect occult …