Trends and patterns in cancer nanotechnology research: A survey of NCI's caNanoLab and nanotechnology characterization laboratory

W Ke, RM Crist, JD Clogston, ST Stern… - Advanced drug delivery …, 2022 - Elsevier
Cancer nanotechnologies possess immense potential as therapeutic and diagnostic
treatment modalities and have undergone significant and rapid advancement in recent …

Biomotors, viral assembly, and RNA nanobiotechnology: Current achievements and future directions

L Rolband, D Beasock, Y Wang, YG Shu… - Computational and …, 2022 - Elsevier
Abstract The International Society of RNA Nanotechnology and Nanomedicine (ISRNN)
serves to further the development of a wide variety of functional nucleic acids and other …

Immunostimulation of Fibrous Nucleic Acid Nanoparticles Can be Modulated through Aptamer-Based Functional Moieties: Unveiling the Structure–Activity …

LP Rebolledo, W Ke, E Cedrone, J Wang… - … Applied Materials & …, 2024 - ACS Publications
Fibrous nanomaterials containing silica, titanium oxide, and carbon nanotubes are
notoriously known for their undesirable inflammatory responses and associated toxicities …

Immunomodulation with Nucleic Acid Nanodevices

F Ding, S Zhang, Q Chen, H Feng, Z Ge, X Zuo, C Fan… - Small, 2023 - Wiley Online Library
The precise regulation of interactions of specific immunological components is crucial for
controllable immunomodulation, yet it remains a great challenge. With the assistance of …

Design and Characterization of Compact, Programmable, Multistranded Nonimmunostimulatory Nucleic Acid Nanoparticles Suitable for Biomedical Applications

R Brumett, L Danai, A Coffman, Y Radwan, M Teter… - Biochemistry, 2024 - ACS Publications
We report a thorough investigation of the role of single-stranded thymidine (ssT) linkers in
the stability and flexibility of minimal, multistranded DNA nanostructures. We systematically …

RNA nanoparticles for targeted therapies of triple-negative breast cancers

L Danai, E Ge, KA Afonin - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Breast cancer represents the most frequently diagnosed malignancy among women with
10%–20% of all cases involving the deadliest of all subtypes, triple-negative breast cancer …

Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology

YI Avila, LP Rebolledo, E Skelly… - ACS Applied Bio …, 2024 - ACS Publications
Nature continually refines its processes for optimal efficiency, especially within biological
systems. This article explores the collaborative efforts of researchers worldwide, aiming to …

Immunostimulatory nucleic acid nanoparticles (NANPs) augment protective osteoblast and osteoclast type I interferon responses to Staphylococcus aureus

EL Mills, YI Avila, D Beasock, Y Radwan… - … , Biology and Medicine, 2024 - Elsevier
Recalcitrant staphylococcal osteomyelitis may be due, in part, to the ability of
Staphylococcus aureus to invade bone cells. However, osteoclasts and osteoblasts are now …

Delivering nucleic acids to immune and non-immune cells

KA Afonin, F Re, D Boraschi - Frontiers in Immunology, 2023 - frontiersin.org
For decades, there has been ongoing research focused on the targeted delivery of
therapeutic DNA and/or RNA molecules designed to regulate the expression of specific …

Advancements in Nanoparticle Characterization

RM Crist, JD Clogston, ST Stern… - … of Nanoparticles Intended …, 2024 - Springer
Nanotechnology for drug delivery has made significant advancements over the last two
decades. Innovations have been made in cancer research and development, including …