Public health burden of non-typhoidal Salmonella strains in sub-Saharan Africa

RY Olobatoke - International Research Journal of Public and …, 2017 - journalissues.org
The impact of non-typhoidal Salmonella (NTS) infections on human and animal health, with
the associated morbidity and mortality is a global issue of public health concern. The …

Invasive Non-Typhoidal Salmonella Lineage Biofilm Formation and Gallbladder Colonization Vary But Do Not Correlate Directly with Known Biofilm-Related …

EM Vasicek, JS Gunn - Infection and immunity, 2023 - Am Soc Microbiol
Non-typhoidal Salmonella (NTS) serovars have a broad host range and cause
gastroenteritis in humans. However, invasive NTS (iNTS) bloodstream infections have …

[HTML][HTML] Rapid transcriptional responses to serum exposure are associated with sensitivity and resistance to antibody-mediated complement killing in invasive …

EM Ondari, EJ Klemm, CL Msefula… - Wellcome open …, 2019 - ncbi.nlm.nih.gov
Background: Salmonella Typhimurium ST313 exhibits signatures of adaptation to invasive
human infection, including higher resistance to humoral immune responses than …

[HTML][HTML] Intestinal inflammation and increased intestinal permeability in Plasmodium chabaudi AS infected mice

JP Mooney, SM DonVito, R Lim, M Keith… - Wellcome open …, 2022 - ncbi.nlm.nih.gov
Background: Gastrointestinal symptoms are commonly associated with acute Plasmodium
spp infection. Malaria-associated enteritis may provide an opportunity for enteric pathogens …

Effectiveness of iNTS vaccination in Sub-Saharan Africa

D Cassese, N Dimitri, G Breghi, T Spadafina - arXiv preprint arXiv …, 2023 - arxiv.org
Invasive non-Typhoidal Salmonella (iNTS) is one of the leading causes of blood stream
infections in Sub-Saharan Africa, especially among children. iNTS can be difficult to …

Nontyphoid salmonella disease

MA Gordon, NA Feasey, TS Nyirenda… - Hunter's Tropical Medicine …, 2020 - Elsevier
Nontyphoidal Salmonella (NTS) typically causes self-limiting enterocolitis in high-income
settings. In sub-Saharan Africa (SSA), however, NTS is a major cause of bloodstream …

[PDF][PDF] Disrupted iron metabolism and mortality during co-infection with malaria and an intestinal gram-negative extracellular pathogen

LI Dos Santos, TA Torres, SQ Diniz, R Goncalves… - Cell Reports, 2021 - cell.com
Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-
negative (Gr−) bacteria. To explore this experimentally, we performed co-infection of mice …

Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand

K Hengkrawit, C Tangjade - Infection and Drug Resistance, 2022 - Taylor & Francis
Purpose Invasive non-typhoidal Salmonella disease, iNTS is a major global health concern,
especially multi-drug resistant non-typhoidal Salmonella, MDR-NTS. Information about risk …

Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK

R Müller, TM Gerwel, MP Kimuda, ÖT Bishop… - RSC Medicinal …, 2021 - pubs.rsc.org
HPPK, which directly precedes DHPS in the folate biosynthetic pathway, is a promising but
chronically under-exploited anti-microbial target. Here we report the identification of new S …

[HTML][HTML] Events associated with susceptibility to invasive Salmonella enterica serovar Typhi in BALB/c mice previously infected with Plasmodium berghei ANKA

YC Moreira, M Jordão, OTF da Costa, E Farias… - Scientific Reports, 2021 - nature.com
Numerous mechanisms have been proposed to explain why patients with malaria are more
susceptible to bloodstream invasions by Salmonella spp., however there are still several …