[HTML][HTML] Exploring the plant-derived bioactive substances as antidiabetic agent: an extensive review
Diabetes mellitus (DM) is a metabolic syndrome. Diabetes has become more common in
recent years. Chemically generated drugs are used to lessen the effects of DM and its …
recent years. Chemically generated drugs are used to lessen the effects of DM and its …
The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …
health. Research has expanded massively since it began in the 1930s, and the complex …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Advances in regenerative stem cell therapy in androgenic alopecia and hair loss: Wnt pathway, growth-factor, and mesenchymal stem cell signaling impact analysis …
P Gentile, S Garcovich - Cells, 2019 - mdpi.com
The use of stem cells has been reported to improve hair regrowth in several therapeutic
strategies, including reversing the pathological mechanisms, that contribute to hair loss …
strategies, including reversing the pathological mechanisms, that contribute to hair loss …
Cell signaling and stress responses
GS Hotamisligil, RJ Davis - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Stress-signaling pathways are evolutionarily conserved and play an important role in the
maintenance of homeostasis. These pathways are also critical for adaptation to new cellular …
maintenance of homeostasis. These pathways are also critical for adaptation to new cellular …
The MAPK pathway across different malignancies: a new perspective
M Burotto, VL Chiou, JM Lee, EC Kohn - Cancer, 2014 - Wiley Online Library
The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway
is activated by upstream genomic events and/or activation of multiple signaling events in …
is activated by upstream genomic events and/or activation of multiple signaling events in …
Effects of apigenin on RBL-2H3, RAW264. 7, and HaCaT cells: anti-allergic, anti-inflammatory, and skin-protective activities
CH Park, SY Min, HW Yu, K Kim, S Kim, HJ Lee… - International Journal of …, 2020 - mdpi.com
Apigenin (4′, 5, 7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …
The clinical development of MEK inhibitors
Y Zhao, AA Adjei - Nature reviews Clinical oncology, 2014 - nature.com
Aberrant activation of the RAS–RAF–MEK–ERK1/2 pathway occurs in more than 30% of
human cancers. As part of this pathway, MEK1 and MEK2 have crucial roles in …
human cancers. As part of this pathway, MEK1 and MEK2 have crucial roles in …
[HTML][HTML] Vascular biology of ageing—Implications in hypertension
A Harvey, AC Montezano, RM Touyz - Journal of molecular and cellular …, 2015 - Elsevier
Ageing is associated with functional, structural and mechanical changes in arteries that
closely resemble the vascular alterations in hypertension. Characteristic features of large …
closely resemble the vascular alterations in hypertension. Characteristic features of large …
Cisplatin: mode of cytotoxic action and molecular basis of resistance
ZH Siddik - Oncogene, 2003 - nature.com
Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …