Modeling prenatal opioid exposure in animals: current findings and future directions

EM Byrnes, FM Vassoler - Frontiers in neuroendocrinology, 2018 - Elsevier
The past decade has seen a drastic rise in the number of infants exposed to opioids in utero.
It is unclear what lasting effect this exposure may have on these children. Animal models of …

Endogenous opiates and behavior: 2016

RJ Bodnar - Peptides, 2018 - Elsevier
This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Prenatal opioid exposure and vulnerability to future substance use disorders in offspring

Y Abu, S Roy - Experimental neurology, 2021 - Elsevier
The heightened incidence of opioid use during pregnancy has resulted in unprecedented
rates of neonates prenatally exposed to opioids. Prenatal opioid exposure (POE) results in …

Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development

SC Simmons, GG Grecco, BK Atwood, FS Nugent - Neuropharmacology, 2023 - Elsevier
In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …

[HTML][HTML] Prenatal opioid exposure enhances responsiveness to future drug reward and alters sensitivity to pain: a review of preclinical models and contributing …

GG Grecco, BK Atwood - eneuro, 2020 - eneuro.org
The opioid crisis has resulted in an unprecedented number of neonates born with prenatal
opioid exposure (POE); however, the long-term effects of POE on offspring behavior and …

Perinatal opioid exposure leads to decreased social play in adolescent male and female rats: Potential role of oxytocin signaling in brain regions associated with …

HJ Harder, CT Searles, ME Vogt, AZ Murphy - Hormones and Behavior, 2023 - Elsevier
Over the last two decades, the number of infants exposed to opioids in utero has quadrupled
in the United States, with some states reporting rates as high as 55 infants per 1000 births …

[HTML][HTML] Effect of rat parental morphine exposure on passive avoidance memory and morphine conditioned place preference in male offspring

A Akbarabadi, S Niknamfar, N Vousooghi… - Physiology & …, 2018 - Elsevier
Drug addiction is a chronic disorder resulted from complex interaction of genetic,
environmental, and developmental factors. Epigenetic mechanisms play an important role in …

Prenatal opioid exposure inhibits microglial sculpting of the dopamine system selectively in adolescent male offspring

CJ Smith, T Lintz, MJ Clark, KE Malacon… - …, 2022 - nature.com
The current opioid epidemic has dramatically increased the number of children who are
prenatally exposed to opioids, including oxycodone. A number of social and cognitive …

Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring

N Vousooghi, MS Sadat-Shirazi, P Safavi… - International Journal of …, 2018 - Elsevier
Addiction to drugs, including opioids is the result of an interplay between environmental and
genetic factors. It has been shown that the progeny of addict people is at higher risk for drug …

Consequences of parental opioid exposure on neurophysiology, behavior, and health in the next generations

FM Vassoler, ME Wimmer - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Substance abuse and the ongoing opioid epidemic represents a large societal burden. This
review will consider the long-term impact of opioid exposure on future generations. Prenatal …