Functional states of myeloid cells in cancer

L van Vlerken-Ysla, YY Tyurina, VE Kagan… - Cancer cell, 2023 - cell.com
Myeloid cells, comprised of macrophages, dendritic cells, monocytes, and granulocytes,
represent a major component of the tumor microenvironment (TME) and are critically …

[HTML][HTML] A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

S Zhou, H You, S Qiu, D Yu, Y Bai, J He, H Cao… - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

PPARα: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases

Y Lin, Y Wang, P Li - Frontiers in Endocrinology, 2022 - frontiersin.org
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is involved in lipid metabolism of various tissues. Different metabolites of fatty …

Nervonic acid and its sphingolipids: Biological functions and potential food applications

NV Phung, F Rong, WY Xia, Y Fan, XY Li… - Critical reviews in …, 2023 - Taylor & Francis
Nervonic acid, a 24-carbon fatty acid with only one double bond at the 9th carbon (C24: 1n-
9), is abundant in the human brain, liver, and kidney. It not only functions in free form but …

Nuclear Receptor PPARα as a Therapeutic Target in Diseases Associated with Lipid Metabolism Disorders

P Hu, K Li, X Peng, Y Kan, H Li, Y Zhu, Z Wang, Z Li… - Nutrients, 2023 - mdpi.com
Lipid metabolic diseases have substantial morbidity and mortality rates, posing a significant
threat to human health. PPARα, a member of the peroxisome proliferator-activated receptors …

Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr−/−. Leiden mice with …

E Gart, W van Duyvenvoorde, MPM Caspers… - The FASEB …, 2022 - Wiley Online Library
Non‐alcoholic steatohepatitis (NASH) is associated with a disturbed metabolism in liver,
insulin resistance, and excessive accumulation of ectopic fat. Branched‐chain amino acids …

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

X Liu, X Xu, T Zhang, L Xu, H Tao, Y Liu… - Phytotherapy …, 2023 - Wiley Online Library
Cardiovascular diseases are currently the primary cause of mortality in the whole world.
Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are …

Omega-3 fatty acids and metabolic partitioning of fatty acids within the liver in the context of nonalcoholic fatty liver disease

PC Calder - Current Opinion in Clinical Nutrition & Metabolic Care, 2022 - journals.lww.com
Omega-3 fatty acids and metabolic partitioning of fatty acid... : Current Opinion in Clinical
Nutrition & Metabolic Care Omega-3 fatty acids and metabolic partitioning of fatty acids within …

Nobiletin ameliorates hepatic lipid deposition, oxidative stress, and inflammation by mechanisms that involve the Nrf2/NF-κB Axis in nonalcoholic fatty liver disease

C Fan, A Ling-Hu, D Sun, W Gao, C Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Nobiletin (NOB), a flavonoid with significant antioxidant potential, holds promise for treating
nonalcoholic fatty liver disease (NAFLD). In this work, we aim to assess the effects and …

A Newly Synbiotic Combination Alleviates Obesity by Modulating the Gut Microbiota–Fat Axis and Inhibiting the Hepatic TLR4/NF‐κB Signaling Pathway

Y Kang, P Ren, X Shen, X Kuang… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Obesity has been recognized as a worldwide public health crisis, this is accompanied
by dysregulation of the intestinal microbiota and upregulation of liver steatosis and adipose …