Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice

E Hodzic, D Imai, S Feng, SW Barthold - PloS one, 2014 - journals.plos.org
The agent of Lyme borreliosis, Borrelia burgdorferi, evades host immunity and establishes
persistent infections in its varied mammalian hosts. This persistent biology may pose …

Elevated levels of IL-23 in a subset of patients with post–Lyme disease symptoms following erythema migrans

K Strle, D Stupica, EE Drouin… - Clinical infectious …, 2014 - academic.oup.com
Background. The causes of post-Lyme disease symptoms are unclear. Herein, we
investigated whether specific immune responses were correlated with such symptoms …

Immune response to Borrelia: lessons from Lyme disease spirochetes

LK Bockenstedt, RM Wooten, N Baumgarth - Current issues in molecular …, 2021 - mdpi.com
The mammalian host responds to infection with Borrelia spirochetes through a highly
orchestrated immune defense involving innate and adaptive effector functions aimed toward …

[HTML][HTML] Lyme disease and the pursuit of a clinical cure

H Adkison, ME Embers - Frontiers in Medicine, 2023 - frontiersin.org
Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-
borne illness in the United States. Many aspects of the disease are still topics of controversy …

Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis

JM Berthelot, J Sellam, Y Maugars, F Berenbaum - Rmd Open, 2019 - rmdopen.bmj.com
DNA of gut microbiota can be found in synovium of osteoarthritis and rheumatoid arthritis.
This finding could result from the translocation of still alive bacteria from gut to joints through …

Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library

J Feng, T Wang, W Shi, S Zhang… - Emerging microbes & …, 2014 - Taylor & Francis
Although antibiotic treatment for Lyme disease is effective in the majority of cases, especially
during the early phase of the disease, a minority of patients suffer from post-treatment Lyme …

Laboratory diagnosis of Lyme borreliosis: Current state of the art and future perspectives

B Lohr, V Fingerle, DE Norris… - Critical reviews in clinical …, 2018 - Taylor & Francis
This review is directed at physicians and laboratory personnel in private practice and clinics
who treat and diagnose Lyme borreliosis (LB) in patients as part of their daily work. A major …

Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding

ME Embers, NR Hasenkampf, MB Jacobs, AC Tardo… - PLoS …, 2017 - journals.plos.org
The efficacy and accepted regimen of antibiotic treatment for Lyme disease has been a point
of significant contention among physicians and patients. While experimental studies in …

Evidence of in vivo existence of Borrelia biofilm in borrelial lymphocytomas

E Sapi, K Balasubramanian, A Poruri… - European Journal of …, 2016 - akjournals.com
Lyme borreliosis, caused by the spirochete Borrelia burgdorferi sensu lato, has grown into a
major public health problem. We recently identified a novel morphological form of B …

[HTML][HTML] Late disseminated Lyme disease: associated pathology and spirochete persistence posttreatment in rhesus macaques

NA Crossland, X Alvarez, ME Embers - The American journal of pathology, 2018 - Elsevier
Nonhuman primates currently serve as the best experimental model for Lyme disease
because of their close genetic homology with humans and demonstration of all three phases …