Introduction: Lyme disease is a tickborne illness that generates controversy among medical
providers and researchers. One of the key topics of debate is the existence of persistent …

OBJECTIVES: The study objective is to demonstrate the clinical and research utility of an
operationalized definition of post-treatment Lyme disease syndrome (PTLDS), as proposed …

Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that
persist despite antibiotic drug therapy. We tested whether those symptoms are caused by …

Is chronic illness in patients with Lyme disease caused by persistent infection? Three
decades of basic and clinical research have yet to produce a definitive answer to this …

Objective: Chronic Lyme disease has been a poorly defined term and often dismissed as a
fictitious entity. In this paper, the International Lyme and Associated Diseases Society …

The controversy regarding the underlying mechanisms of PTLDs and the increasingly bitter
debate over CLD, continues unabated over the past years. If anything, it has become more …

The annual incidence of Lyme disease, caused by tick-transmitted Borreliella burgdorferi, is
estimated to be at least 476,000 cases in the United States and many more worldwide. Ten …

Whether Borrelia burgdorferi, the causative agent of Lyme disease, can persist for long
periods in the human body has been a controversial question. The objective of this study …

Lyme disease, caused by spirochetes of the Borrelia burgdorferi sensu lato complex
(hereinafter referred to as Lyme borrelia), is the most common tick-borne infection in the …

Lyme disease is a complex tick-borne zoonosis that poses an escalating public health threat
in several parts of the world, despite sophisticated healthcare infrastructure and decades of …