Recent studies have shown that Borrelia burgdorferi can form antibiotic-tolerant persisters in
the presence of microbiostatic drugs such as doxycycline. Precisely how this occurs is yet …

Introduction Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense
against infection. However, these cells have not yet been examined in patients with Lyme …

Objective. To determine whether second-line intraarticular glucocorticoid (IAGC) injection
improves outcomes in children with persistently active Lyme arthritis after initial antibiotics …

In previous studies, we showed that fibroblast growth factor receptors (FGFRs) contribute to
inflammatory mediator output from primary rhesus microglia in response to live Borrelia …

Background Marked functional impairment has been reported by patients with post-
treatment Lyme disease syndrome (PTLDS). Objective We sought to identify the clinical …

" Superbly written and researched."—Booklist" Builds a strong case."—Kirkus Lyme disease
is spreading rapidly around the globe as ticks move into places they could not survive …

Lyme disease (LD) is an increasingly prevalent, climate change-accelerated, vector-borne
infectious disease with significant morbidity and cost in a proportion of patients who …

Background: Lyme disease (LD) is a tick-borne infection caused by Borrelia burgdorferi
sensu lato. The current therapeutic approach to this disease is limited to antibiotics …

Abstract Background. Most patients with Lyme disease (LD) can be treated effectively with 2–
4 weeks of antibiotics. The Infectious Disease Society of America guidelines do not currently …

Borrelia burgdorferi, the causative agent of Lyme disease, utilizes manganese (Mn) for its
various metabolic needs. We hypothesized that blocking Mn transporter could be a possible …