Background The findings of randomised controlled trials (RCT), observational studies, and
meta-analyses vary regarding the effectiveness of prolonged β-lactam infusion. We aimed to …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Introduction Several reports have shown marked heterogeneity of antibiotic
pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes …

Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …

Objectives Emerging evidence supports the use of therapeutic drug monitoring (TDM) of β-
lactams for intensive care unit (ICU) patients to optimize drug exposure, although limited …

Objectives We utilized the database of the Defining Antibiotic Levels in Intensive care unit
patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and …

Ceftolozane/tazobactam is an antipseudomonal antibacterial approved for the treatment of
complicated urinary tract infections (cUTIs) and complicated intra‐abdominal infections …

Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …

Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …