Next generation gold drugs and probes: chemistry and biomedical applications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …
Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles
Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has
numerous biomedical applications. Bismuth-based compounds are used extensively as …
numerous biomedical applications. Bismuth-based compounds are used extensively as …
In-cell structural biology by NMR: the benefits of the atomic scale
FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …
acids in their native, cellular environment. This emerging field holds great promise and is …
Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance
The rapid emergence of drug resistant Staphylococcus aureus (S. aureus) poses a serious
threat to public health globally. Silver (Ag)-based antimicrobials are promising to combat …
threat to public health globally. Silver (Ag)-based antimicrobials are promising to combat …
Target profiling of an iridium (III)-based immunogenic cell death inducer unveils the engagement of unfolded protein response regulator BiP
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …
Pt (II) and Au (III) complexes containing Schiff-base ligands: A promising source for antitumor treatment
Y Sun, Y Lu, M Bian, Z Yang, X Ma, W Liu - European Journal of Medicinal …, 2021 - Elsevier
The effective application of cisplatin in the clinic as an antitumor treatment has stimulated
widespread interest in inorganic metal drugs. In particular, complexes containing the …
widespread interest in inorganic metal drugs. In particular, complexes containing the …
Mitochondrial ATP synthase as a direct molecular target of chromium (III) to ameliorate hyperglycaemia stress
Chromium (III) is extensively used as a supplement for muscle development and the
treatment of diabetes mellitus. However, its mode of action, essentiality, and physiological …
treatment of diabetes mellitus. However, its mode of action, essentiality, and physiological …
Metalloproteomics for biomedical research: methodology and applications
Metals are essential components in life processes and participate in many important
biological processes. Dysregulation of metal homeostasis is correlated with many diseases …
biological processes. Dysregulation of metal homeostasis is correlated with many diseases …
New Schiff base ligand and its novel Cr (III), Mn (II), Co (II), Ni (II), Cu (II), Zn (II) complexes: spectral investigation, biological applications, and semiconducting …
MA El-Ghamry, FM Elzawawi, AAA Aziz, KM Nassir… - Scientific Reports, 2022 - nature.com
New Schiff base ligand, derived from antiviral valacyclovir, and its novel Cr (III), Mn (II), Co
(II), Ni (II), Cu (II), Zn (II) complexes have been synthesized. By using a variety of analytical …
(II), Ni (II), Cu (II), Zn (II) complexes have been synthesized. By using a variety of analytical …