Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles

DM Griffith, H Li, MV Werrett, PC Andrews… - Chemical Society …, 2021 - pubs.rsc.org
Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has
numerous biomedical applications. Bismuth-based compounds are used extensively as …

In-cell structural biology by NMR: the benefits of the atomic scale

FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance

H Wang, M Wang, X Xu, P Gao, Z Xu, Q Zhang… - Nature …, 2021 - nature.com
The rapid emergence of drug resistant Staphylococcus aureus (S. aureus) poses a serious
threat to public health globally. Silver (Ag)-based antimicrobials are promising to combat …

Target profiling of an iridium (III)-based immunogenic cell death inducer unveils the engagement of unfolded protein response regulator BiP

X Xiong, KB Huang, Y Wang, B Cao… - Journal of the …, 2022 - ACS Publications
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …

Pt (II) and Au (III) complexes containing Schiff-base ligands: A promising source for antitumor treatment

Y Sun, Y Lu, M Bian, Z Yang, X Ma, W Liu - European Journal of Medicinal …, 2021 - Elsevier
The effective application of cisplatin in the clinic as an antitumor treatment has stimulated
widespread interest in inorganic metal drugs. In particular, complexes containing the …

Mitochondrial ATP synthase as a direct molecular target of chromium (III) to ameliorate hyperglycaemia stress

H Wang, L Hu, H Li, YT Lai, X Wei, X Xu, Z Cao… - Nature …, 2023 - nature.com
Chromium (III) is extensively used as a supplement for muscle development and the
treatment of diabetes mellitus. However, its mode of action, essentiality, and physiological …

Metalloproteomics for biomedical research: methodology and applications

Y Zhou, H Li, H Sun - Annual Review of Biochemistry, 2022 - annualreviews.org
Metals are essential components in life processes and participate in many important
biological processes. Dysregulation of metal homeostasis is correlated with many diseases …

New Schiff base ligand and its novel Cr (III), Mn (II), Co (II), Ni (II), Cu (II), Zn (II) complexes: spectral investigation, biological applications, and semiconducting …

MA El-Ghamry, FM Elzawawi, AAA Aziz, KM Nassir… - Scientific Reports, 2022 - nature.com
New Schiff base ligand, derived from antiviral valacyclovir, and its novel Cr (III), Mn (II), Co
(II), Ni (II), Cu (II), Zn (II) complexes have been synthesized. By using a variety of analytical …