Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …

Lower respiratory viral infections, such as influenza virus and severe acute respiratory
syndrome coronavirus 2 infections, often cause severe viral pneumonia in aged individuals …

Alterations in the immune system with aging are considered to underlie many age-related
diseases. However, many elderly individuals remain healthy until even a very advanced …

We are just beginning to understand the diversity of the peripheral T cell compartment,
which arises from the specialization of different T cell subsets and the plasticity of individual …

Age-associated changes in the T cell compartment are well described. However, limitations
of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq …

The strength of the T cell receptor interaction with self-ligands affects antigen-specific
immune responses. However, the precise function and underlying mechanisms are unclear …

Lymphocytes can be functionally partitioned into subsets belonging to the innate or adaptive
arms of the immune system. Subsets of innate and innate-like lymphocytes may or may not …

Effective responses to intracellular pathogens are characterized by T cell clones with a
broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell …

Abstract CD8 virtual memory T (T VM) cells are Ag-naive CD8 T cells that have undergone
partial differentiation in response to common γ-chain cytokines, particularly IL-15 and IL-4. T …