The challenge and prospect of mRNA therapeutics landscape

Y Weng, C Li, T Yang, B Hu, M Zhang, S Guo… - Biotechnology …, 2020 - Elsevier
Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

[HTML][HTML] The function and clinical application of extracellular vesicles in innate immune regulation

X Zhou, F Xie, L Wang, L Zhang, S Zhang… - Cellular & molecular …, 2020 - nature.com
The innate immune system plays a crucial role in the host defense against viral and
microbial infection. Exosomes constitute a subset of extracellular vesicles (EVs) that can be …

Dendritic cell-based immunotherapy: a basic review and recent advances

J Constantino, C Gomes, A Falcão, BM Neves… - Immunologic …, 2017 - Springer
Dendritic cells (DCs) are considered a very promising arm to activate the immune system in
immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting …

Dendritic cell therapy in cancer treatment; the state-of-the-art

M Sadeghzadeh, S Bornehdeli… - Life sciences, 2020 - Elsevier
Dendritic cells (DCs) are considered as professional antigen presenting cells (APCs),
containing a variety of subsets, that can be resident in organs or migrating among the …

The distinct roles of exosomes in innate immune responses and therapeutic applications in cancer

J Rezaie, T Etemadi, M Feghhi - European journal of pharmacology, 2022 - Elsevier
The innate immune system is one of the major constituents of the host's defense against
invading pathogens and extracellular vesicles (EVs) are involved in regulating its …

[HTML][HTML] Recent advances in experimental dendritic cell vaccines for cancer

IY Filin, KV Kitaeva, CS Rutland, AA Rizvanov… - Frontiers in …, 2021 - frontiersin.org
The development of immunotherapeutic methods for the treatment of oncological diseases
have made it possible to improve the effectiveness of standard therapies. There was no …

mRNA-based dendritic cell vaccines

D Benteyn, C Heirman, A Bonehill… - Expert review of …, 2015 - Taylor & Francis
Cancer immunotherapy has been proposed as a powerful treatment modality. Active
immunotherapy aspires to stimulate the patient's immune system, particularly T cells. These …

[HTML][HTML] Dendritic cell vaccines in breast cancer: Immune modulation and immunotherapy

D Qian, J Li, M Huang, Q Cui, X Liu, K Sun - Biomedicine & …, 2023 - Elsevier
Breast cancer (BC) is the most common cancer in women worldwide. Although substantial
progress has been made in the diagnosis and treatment of breast cancer, the efficacy and …

Microtubule-depolymerizing agents used in antibody–drug conjugates induce antitumor immunity by stimulation of dendritic cells

P Müller, K Martin, S Theurich, J Schreiner… - Cancer immunology …, 2014 - AACR
Antibody–drug conjugates (ADC) are emerging as powerful treatment strategies with
outstanding target-specificity and high therapeutic activity in patients with cancer …

[HTML][HTML] Dendritic cells in anticancer vaccination: rationale for ex vivo loading or in vivo targeting

AV Baldin, LV Savvateeva, AV Bazhin, AA Zamyatnin Jr - Cancers, 2020 - mdpi.com
Dendritic cells (DCs) have shown great potential as a component or target in the landscape
of cancer immunotherapy. Different in vivo and ex vivo strategies of DC vaccine generation …