Circadian rhythms in neurodegenerative disorders

M Nassan, A Videnovic - Nature Reviews Neurology, 2022 - nature.com
Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Circadian disruption and sleep disorders in neurodegeneration

Y Shen, Q Lv, W Xie, S Gong, S Zhuang, J Liu… - Translational …, 2023 - Springer
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …

A novel targeted and high‐efficiency nanosystem for combinational therapy for Alzheimer's disease

H Yang, W Mu, D Wei, Y Zhang, Y Duan… - Advanced …, 2020 - Wiley Online Library
Alzheimer's disease (AD) remains the most prevalent neurodegenerative disease, and no
effective treatment is available yet. Metal‐ion‐triggered aggregates of amyloid‐beta (Aβ) …

Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer's disease

BA Kent, HH Feldman, HB Nygaard - Progress in neurobiology, 2021 - Elsevier
A majority of patients with Alzheimer's disease (AD) experience some form of sleep
disruption, including nocturnal sleep fragmentation, increased daytime napping, decreased …

[HTML][HTML] A high-sucrose diet aggravates Alzheimer's disease pathology, attenuates hypothalamic leptin signaling, and impairs food-anticipatory activity in APPswe …

SHH Yeh, FS Shie, HK Liu, HH Yao, PC Kao… - Neurobiology of …, 2020 - Elsevier
High-fat and high-sugar diets contribute to the prevalence of type 2 diabetes and
Alzheimer's disease (AD). Although the impact of high-fat diets on AD pathogenesis has …

Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Aβ accumulation in mice

R Jagirdar, CH Fu, J Park, BF Corbett… - Science translational …, 2021 - science.org
Sleep disruptions promote increases of amyloid β (Aβ) and tau in the brain and increase
Alzheimer's disease (AD) risk, but the precise mechanisms that give rise to sleep …

Multicenter study on sleep and circadian alterations as objective markers of mild cognitive impairment and Alzheimer's disease reveals sex differences

B Guarnieri, M Maestri, F Cucchiara… - Journal of …, 2020 - content.iospress.com
Background: Circadian and sleep disturbances are associated with increased risk of mild
cognitive impairment (MCI) and Alzheimer's disease (AD). Wearable activity trackers could …

Sleep disorders in Alzheimer's disease: the predictive roles and potential mechanisms

H Kuang, YG Zhu, ZF Zhou, MW Yang… - Neural Regeneration …, 2021 - journals.lww.com
Sleep disorders are common in patients with Alzheimer's disease, and can even occur in
patients with amnestic mild cognitive impairment, which appears before Alzheimer's …

Neuronal hyperexcitability in APP SWE/PS1dE9 mouse models of Alzheimer's disease

L Müller, T Kirschstein, R Köhling… - Journal of …, 2021 - content.iospress.com
Transgenic mouse models serve a better understanding of Alzheimer's disease (AD)
pathogenesis and its consequences on neuronal function. Well-known and broadly used AD …

[HTML][HTML] Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits

J Van Erum, D Van Dam, R Sheorajpanday… - Behavioural Brain …, 2019 - Elsevier
Abstract Alzheimer's disease (AD), which accounts for most of the dementia cases, is, aside
from cognitive deterioration, often characterized by the presence of non-cognitive symptoms …