Asthma: from bronchoconstriction to airways inflammation and remodeling

J Bousquet, PK Jeffery, WW Busse… - American journal of …, 2000 - atsjournals.org
Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Nuclear factor-κB: its role in health and disease

A Kumar, Y Takada, AM Boriek… - Journal of molecular …, 2004 - Springer
Nuclear factor-κB (NF-κB) is a major transcription factor that plays an essential role in
several aspects of human health including the development of innate and adaptive …

International consensus on (ICON) pediatric asthma

NG Papadopoulos, H Arakawa, KH Carlsen… - Allergy, 2012 - Wiley Online Library
Asthma is the most common chronic lower respiratory disease in childhood throughout the
world. Several guidelines and/or consensus documents are available to support medical …

Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study

SA Johannesdottir, E Horváth-Puhó… - JAMA internal …, 2013 - jamanetwork.com
Importance Excess endogenous cortisol has been linked to venous thromboembolism (VTE)
risk, but whether this relationship applies to exogenous glucocorticoids remains uncertain …

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

PG Woodruff, HA Boushey… - Proceedings of the …, 2007 - National Acad Sciences
Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and
other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute …

Molecular control of immune/inflammatory responses: interactions between nuclear factor-κB and steroid receptor-signaling pathways

LI McKay, JA Cidlowski - Endocrine reviews, 1999 - academic.oup.com
Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB
and Steroid Receptor-Signaling Pathways | Endocrine Reviews | Oxford Academic Skip to …

Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma

GW Chalmers, KJ Macleod, SA Little, LJ Thomson… - Thorax, 2002 - thorax.bmj.com
Background: Although inhaled corticosteroids have an established role in the treatment of
asthma, studies have tended to concentrate on non-smokers and little is known about the …

Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

A Hafezi-Moghadam, T Simoncini, Z Yang… - Nature medicine, 2002 - nature.com
Corticosteroids have been shown to exert beneficial effects in the treatment of acute
myocardial infarction, but the precise mechanisms underlying their protective effects are …

Efficacy and safety of inhaled corticosteroids: new developments

PJ Barnes, S Pedersen, WW Busse - American journal of respiratory …, 1998 - atsjournals.org
Inhaled corticosteroids have revolutionized the treatment of asthma and have now become
the mainstay of therapy for patients with chronic disease (1). In a supplement to this journal …

Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: a mechanism for …

JC Webster, RH Oakley, CM Jewell… - Proceedings of the …, 2001 - National Acad Sciences
Inflammatory responses in many cell types are coordinately regulated by the opposing
actions of NF-κB and the glucocorticoid receptor (GR). The human glucocorticoid receptor …