Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …

The success of disease-modifying osteoarthritis drug (DMOAD) development is still elusive.
While there have been successes in preclinical and early clinical studies, phase 3 clinical …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading
articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA …

Osteoarthritis is a common progressive joint disease. As no effective medical interventions
are available, osteoarthritis often progresses to the end stage, in which only surgical options …

Objective Osteoarthritis (OA) is a common disease with complex and unclear pathogenesis.
Ferroptosis is a new cell death mode, which is proved to be involved in different kinds of …

Abstract Purpose of Review In this review article, we discuss the potential for employing
nanotechnological strategies for the diagnosis, monitoring, and clinical management of …

Background Osteoarthritis (OA) is one of the most prevalent and degenerative diseases with
complicated pathology including articular cartilage degradation, subchondral sclerosis and …

The remarkable lubrication properties of normal articular cartilage play an essential role in
daily life, providing almost frictionless movements of joints. Alterations of cartilage surface or …

Biomarkers, especially biochemical markers, are important in osteoarthritis (OA) research,
clinical trials, and drug development and have potential for more extensive use in …

Objectives This study aims to investigate the effects of Icariin (ICA) on interleukin-1β (IL-1β)-
induced osteoarthritis (OA) and its potential mechanism of action. Methods SW1353 …