Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

Anxiety and stress-related disorders are severe psychiatric conditions that affect
performance in daily tasks and represent a high cost to public health. The initial observation …

Animal models have proven to be invaluable to researchers trying to answer questions
regarding the mechanisms of behavior. The Open Field Maze is one of the most commonly …

To study brain function, preclinical research heavily relies on animal monitoring and the
subsequent analyses of behavior. Commercial platforms have enabled semi high …

The light/dark test is based on the innate aversion of rodents to brightly illuminated areas
and on the spontaneous exploratory behaviour of rodents in response to mild stressors, that …

Anxiety is a psychological, physiological, and behavioral state induced in animals and
humans by a threat to well-being or survival, either actual or potential. It is characterized by …

In various areas of the bio-medical, pharmacological and psychological research a multitude
of behavioural tests have been used to investigate the effects of environmental, genetic and …

The elevated plus-maze test has been in use as a rodent model of anxiety for a decade, and
is representative of those tests that are based upon the study of spontaneous behaviour …

Objective Traumatic brain injury (TBI) is a recognized risk factor for later development of
neurodegenerative disease. However, the mechanisms contributing to neurodegeneration …

The elevated plus-maze test (PM) and open-field test (OF) are routinely used to study
anxiety-related behaviour in mouse. However, the data obtained with these tests have often …