Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

Background Controlled release and targeted delivery of the drug payload are the two most
fascinating applications of nanoparticle-based systems explored in the recent past. The …

The treatment of central nervous system (CNS) disorders always remains a challenge for the
researchers. The presence of various physiological barriers, primarily the blood–brain …

The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …

Nanomedicine is currently focused on the design and development of nanocarriers that
enhance drug delivery to the brain to address unmet clinical needs for treating …

Nasal drug delivery has been employed as an alternate and convenient route for the
systemic availability of pharmaceuticals, particularly for potent therapeutics. This is owing to …

The present work focuses on the development of surface modified transferrin PLGA
nanoparticles loaded with clonidine for nose to brain delivery. The CLD-Tf-PLGA-NPs were …

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease with
unknown etiology that can be characterized by the presence of demyelinated lesions …

With the increasingly widespread of central nervous system (CNS) disorders and the lack of
sufficiently effective medication, meloxicam (MEL) has been reported as a possible …