Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

Á Nagy, A Lánczky, O Menyhárt, B Győrffy - Scientific reports, 2018 - nature.com
Multiple studies suggested using different miRNAs as biomarkers for prognosis of
hepatocellular carcinoma (HCC). We aimed to assemble a miRNA expression database …

The implications of ncRNAs in the development of human diseases

E López-Jiménez, E Andrés-León - Non-coding RNA, 2021 - mdpi.com
The mammalian genome comprehends a small minority of genes that encode for proteins
(barely 2% of the total genome in humans) and an immense majority of genes that are …

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

D Repana, J Nulsen, L Dressler, M Bortolomeazzi… - Genome biology, 2019 - Springer
Abstract The Network of Cancer Genes (NCG) is a manually curated repository of 2372
genes whose somatic modifications have known or predicted cancer driver roles. These …

[HTML][HTML] Detection of circulating exosomal miR-17-5p serves as a novel non-invasive diagnostic marker for non-small cell lung cancer patients

Y Zhang, Y Zhang, Y Yin, S Li - Pathology-Research and Practice, 2019 - Elsevier
Exosome-shuttled bioactive miRNAs act as novel non-invasive biomarkers for cancer
diagnosis have received increasing attention. In this study, we aimed to investigate the …

miR‐24‐3p promotes cell migration and proliferation in lung cancer by targeting SOX7

L Yan, J Ma, Y Zhu, J Zan, Z Wang… - Journal of cellular …, 2018 - Wiley Online Library
Lung cancer (LC) is one of the leading causes of cancer‐related death in the world. miR‐24‐
3p plays critical roles in many cancer types, including LC. In this study, we first investigated …

Epigenetic basis and targeting of cancer metastasis

R Banerjee, J Smith, MR Eccles, RJ Weeks… - Trends in Cancer, 2022 - cell.com
Despite the development of novel therapeutic approaches and improved clinical
management, survival from metastatic disease remains poor. Indeed, metastasis accounts …

Downregulation of miR-99b-5p and upregulation of nuclear mTOR cooperatively promotes the tumor aggressiveness and drug resistance in African American prostate …

H Gujrati, S Ha, M Waseem, BD Wang - International Journal of Molecular …, 2022 - mdpi.com
Mammalian target of rapamycin (mTOR) regulates various fundamental cellular events
including cell proliferation, protein synthesis, metabolism, apoptosis, and autophagy. Tumor …

Gene expression changes in irradiated baboons: a summary and interpretation of a decade of findings

M Port, F Hérodin, M Drouet, M Valente… - Radiation …, 2021 - meridian.allenpress.com
To understand and improve the field of medical management of the acute radiation
syndrome (ARS), military and civilian radiobiology institutions joined one of NATO's Human …

[HTML][HTML] Curcumin enhances radiosensitization of nasopharyngeal carcinoma via mediating regulation of tumor stem-like cells by a CircRNA network

D Zhu, M Shao, J Yang, M Fang, S Liu, D Lou… - Journal of …, 2020 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs,
which are associated with differentiation, proliferation, migration, and carcinogenicity …

Tumor suppressive miR-99b-5p as an epigenomic regulator mediating mTOR/AR/SMARCD1 signaling axis in aggressive prostate cancer

M Waseem, H Gujrati, BD Wang - Frontiers in Oncology, 2023 - frontiersin.org
Introduction African American (AA) men exhibited 2.3-fold higher PCa incidence and 1.7-fold
higher PCa mortality rates when compared to the European American (EA) men. Besides …