The clinical use of doxorubicin in cancer is limited by cardiotoxic effects that can lead to
heart failure. Whereas earlier work focused on the direct impact of doxorubicin on …

Rapid signaling of estrogen involves membrane estrogen receptors (ERs), including
membrane subpopulations of ERα and ERβ. In the mid-1990s, several laboratories …

Background Lymphatic vessels interconnect with blood vessels to form an elaborate system
that aids in the control of tissue pressure and edema formation. Although the lymphatic …

Doxorubicin (DOX) is a highly effective chemotherapy agent that often causes cardiotoxicity.
Despite a number of extensive studies, the risk for DOX cardiotoxicity remains unpredictable …

Cardiac metabolic stress is a hallmark of many cardiac pathologies, including diabetes.
Cardiac glycogen mis-handling is a frequent manifestation of various cardiopathologies …

Background In addition to their crucial role in reproduction, estrogens are key regulators of
energy and glucose homeostasis and they also exert several cardiovascular protective …

We examined the impact of sex on high-fat diet (HFD)–induced renal alterations in Dahl salt-
sensitive and Sprague Dawley rats. In Dahl rats, HFD (60% kcal from fat for 24–26 weeks …

Background DJ‐1 is a ubiquitously expressed protein typically associated with the
development of early onset Parkinson disease. Recent data suggest that it also plays a role …

Previous studies have demonstrated that T-helper 17 (TH17) cells and cytolytic natural killer
(cNK) cells are increased in women with preeclampsia. In this study we investigated the role …

The incidence of cardiac hypertrophy, an established risk factor for heart failure, is generally
lower in women compared with men, but this advantage is lost after menopause. Although it …