The adenosine A2A receptor subtype is recognized as a non-dopaminergic
pharmacological target for the treatment of neurodegenerative disorders, notably …

Adenosine and adenosine receptors (ARs) are increasingly recognized as important
therapeutic targets for controlling cognition under normal and disease conditions for its dual …

Cholesterol has been linked to the pathogenesis of sporadic Alzheimer's disease (AD) as a
risk factor increasing β-amyloid (Aβ) and oxidative stress levels. Caffeine has antioxidant …

Bursting activity of striatal medium spiny neurons results from membrane potential
oscillations between a down-and an upstate that could be regulated by G-protein-coupled …

Caffeine is the most widely consumed psychostimulant substance, being self-administered
throughout a wide range of conditions and present in numerous dietary products. Due to its …

The prevalence of Parkinson's disease (PD) increases with age and is projected to increase
in parallel to the rising average age of the population. The disease can have significant …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Adenosine and endocannabinoids are very ubiquitous non‐classical neurotransmitters that
exert a modulatory role on the transmission of other more 'classical'neurotransmitters. In this …

Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that regulates
several important functions in the central nervous system. Large amount of preclinical data …

Caffeine is the most consumed psychoactive drug in the world. It is a non-selective
adenosine receptor antagonist that in the brain targets mainly adenosine A 1 and A 2A …