Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

A historical review of brain drug delivery

WM Pardridge - Pharmaceutics, 2022 - mdpi.com
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

[HTML][HTML] Plant-derived exosome-like nanoparticles and their therapeutic activities

J Kim, S Li, S Zhang, J Wang - Asian journal of pharmaceutical sciences, 2022 - Elsevier
Nanotechnologies have been successfully applied to the treatment of various diseases.
Plant-derived exosome-like nanoparticles (PENs) are expected to become effective …

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

Oxytocin-dependent reopening of a social reward learning critical period with MDMA

R Nardou, EM Lewis, R Rothhaas, R Xu, A Yang… - Nature, 2019 - nature.com
A critical period is a developmental epoch during which the nervous system is expressly
sensitive to specific environmental stimuli that are required for proper circuit organization …

The physiological control of eating: signals, neurons, and networks

AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy

AM Angelidi, MJ Belanger, A Kokkinos… - Endocrine …, 2022 - academic.oup.com
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

Brain oxytocin: how puzzle stones from animal studies translate into psychiatry

V Grinevich, ID Neumann - Molecular psychiatry, 2021 - nature.com
The neuropeptide oxytocin has attracted great attention of the general public, basic
neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social …

Roles of oxytocin in stress responses, allostasis and resilience

Y Takayanagi, T Onaka - International journal of molecular sciences, 2021 - mdpi.com
Oxytocin has been revealed to work for anxiety suppression and anti-stress as well as for
psychosocial behavior and reproductive functions. Oxytocin neurons are activated by …

Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development

GF Koob - Pharmacological Reviews, 2021 - ASPET
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …