Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

Metal–organic cages (MOCs) have become an intensely studied class of abiotic host
molecules. This is due to the ability to generate a myriad of polyhedral architectures from …

Molecular similarity is a key concept in drug discovery. It is based on the assumption that
structurally similar molecules frequently have similar properties. Assessment of similarity …

Computational chemistry—in particular, virtual screening—can provide valuable
contributions in hit-and lead-compound discovery. Numerous software tools have been …

The chemical space is the ensemble of all possible molecules, which is believed to contain
at least 1060 organic molecules below 500 Da of possible interest for drug discovery. This …

The applied use of in silico technologies (aka computational toxicology, in silico toxicology,
computer-assisted tox, e-tox, i-drug discovery, predictive ADME, etc.) for predicting …

One approach to speed up drug discovery is to examine new uses for existing approved
drugs, so-called 'drug repositioning'or 'drug repurposing', which has become increasingly …

Background Immunoassays are widely used in clinical laboratories for measurement of
plasma/serum concentrations of steroid hormones such as cortisol and testosterone …

Natural products are continually explored in the development of new bioactive compounds
with industrial applications, attracting the attention of scientific research efforts due to their …

Cysteine-focused chemical proteomic platforms have accelerated the clinical development
of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic …