Current views on in vivo models for breast cancer research and related drug development
T Ferreira, T Azevedo, J Silva… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Animal models play a crucial role in breast cancer research, in particular mice
and rats, who develop mammary tumors that closely resemble their human counterparts …
and rats, who develop mammary tumors that closely resemble their human counterparts …
Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial …
T Amin, RP Sharma, KB Mir, N Slathia… - European Journal of …, 2023 - Elsevier
AKT and ERK 1/2 play a pivotal role in cancer cell survival, proliferation, migration, and
angiogenesis. Therefore, AKT and ERK 1/2 are considered crucial targets for cancer …
angiogenesis. Therefore, AKT and ERK 1/2 are considered crucial targets for cancer …
Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy
CYP2C8 is a crucial CYP isoform responsible for the metabolism of xenobiotics and
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of …
A Jamwal, J Chand, A Dash, S Bhatt, S Dhiman… - Chemico-Biological …, 2023 - Elsevier
In spite of unprecedented advances in modern cancer therapy, there is still a dearth of
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …
Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology
J Lu, F Xu, C Rao, C Shen, J Jin, Z Zhu… - Frontiers in …, 2022 - frontiersin.org
Paclitaxel is an herbal active ingredient used in clinical practice that shows anti-tumor
effects. However, its biological activity, mechanism, and cancer cell-killing effects remain …
effects. However, its biological activity, mechanism, and cancer cell-killing effects remain …
ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features
Crocetin is a promising phyto-based molecule to treat Alzheimer's disease (AD). The
chemical structure of crocetin is incongruent with various standard structural features of CNS …
chemical structure of crocetin is incongruent with various standard structural features of CNS …
Canonical DDR activation by EMT inducing agent 5-Fluorouracil is modulated by a cannabinoid based combinatorial approach via inducing autophagy and …
Anastasis cascade including induction of Epithelial to Mesenchymal Transition (EMT), DNA
repair, and stimulation of pro-survival mediators collectively exaggerate therapy resistance …
repair, and stimulation of pro-survival mediators collectively exaggerate therapy resistance …
In-vitro Anti-inflammatory Potential of Standardized Rottlerin Enriched Fraction of Mallotus philippensis Muell. Arg Anti-inflammatory Potential of Rottlerin Enriched …
A rottlerin enriched fraction was prepared from extract of Mallotus philippensis Muell. Arg
leaves in ethyl acetate using HP-20 dianion polymeric resin. The procedure of extraction …
leaves in ethyl acetate using HP-20 dianion polymeric resin. The procedure of extraction …
Narrative Testimony and Characteristics of Rottlerin for the Treatment of Various Kinds of Cancer
From ancient times until now, scientists have focused on herbal medicaments for treating
various diseases. Rottlerin, a potent PKCδ inhibitor, is one of the greatest herbal …
various diseases. Rottlerin, a potent PKCδ inhibitor, is one of the greatest herbal …
Tetrahydrocannabinol derivative ameliorates 5-FU mediated DNA damage propensity coupled with Vimentin suppression leading to autophagy induction
Anastasis cascade including induction of Epithelial to Mesenchymal Transition (EMT), DNA
repair, and stimulation of pro-survival mediators collectively exaggerate therapy resistance …
repair, and stimulation of pro-survival mediators collectively exaggerate therapy resistance …