The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Carbohydrates play essential roles in nature, such as in cell–cell communication, cell growth
and immunoresponse. However, the synthesis of structurally well-defined carbohydrates …

The intrinsic complexity of carbohydrate structures has hampered access to pure glycans
and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has …

RN1, a highly branched arabinogalactan isolated from the flower of Panax notoginseng,
possesses a potent ability to inhibit the development of pancreatic cancer. Due to the …

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable.
We have developed a database of acceptor nucleophilic constants (Aka) to quantify the …

A dense hydrogen‐bond network is responsible for the mechanical and structural properties
of polysaccharides. Random derivatization alters the properties of the bulk material by …

A novel one-pot relay glycosylation has been established. The protocol is characterized by
the construction of two glycosidic bonds with only one equivalent of triflic anhydride. This …

Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly,
glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host …

Oligosaccharides are the ubiquitous molecules of life. In order to translate human
bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and …