The organization, regulation and dynamical responses of biological systems are in many
cases too complex to allow intuitive predictions and require the support of mathematical …

Butanol has similar characteristics to gasoline, and could provide an alternative oxygenate
to ethanol in blended fuels. Butanol can be produced either via the biotechnological route …

Computational procedures for predicting metabolic interventions leading to the
overproduction of biochemicals in microbial strains are widely in use. However, these …

Optimization aims to make a system or design as effective or functional as possible.
Mathematical optimization methods are widely used in engineering, economics and science …

Worldwide demand for energy has been the impetus for research to produce alcohol
biofuels from renewable resources. This review focuses on the biosynthesis of butanol …

Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

This year we celebrate the 150th anniversary of the law of mass action. This law is often
assumed to have been “there” forever, but it has its own history, background, and a definite …

Rationale: Modern molecular biology is generating data of unprecedented quantity and
quality. Particularly exciting for biochemical pathway modeling and proteomics are …

Issues of regulation and control are central to the study of biological and biochemical
systems. Thus it is not surprising that the tools of feedback control theory--engineering …

A First Course in Systems Biology is an introduction for advanced undergraduate and
graduate students to the growing field of systems biology. Its main focus is the development …