Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

Long-lasting, latently infected resting CD4+ T cells are the greatest obstacle to obtaining a
cure for HIV infection, as these cells can persist despite decades of treatment with …

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host
characteristics associated with reservoir size and long-term dynamics in 1,057 individuals …

Background HIV-1 proviruses persist in people on antiretroviral therapy (ART) but most are
defective and do not constitute a replication-competent reservoir. The decay of infected cells …

Latent intact HIV-1 proviruses persist in a small subset of long-lived CD4+ T cells that can
undergo clonal expansion in vivo. Expanded clones of CD4+ T cells dominate latent …

Clonal expansion of HIV-infected cells contributes to the long-term persistence of the HIV
reservoir in ART-suppressed individuals. However, the contribution from cell clones that …

A cure for HIV infection remains elusive due to the persistence of replication-competent HIV
proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite …

Gene editing using CRISPR/Cas9 is a promising method to cure many human genetic
diseases. We have developed an efficient system to deliver Cas9 into the adeno-associated …

The human immunodeficiency virus (HIV) infection of the immune cells expressing the
cluster of differentiation 4 cell surface glycoprotein (CD4+ cells) causes progressive decline …