The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

Mobility is the most studied and most relevant physical ability affecting quality of life with
strong prognostic value for disability and survival. Natural selection has built the “engine” of …

Aging is characterized by a progressive loss of tissue and organ function due to genetic and
environmental factors, nutrition, and lifestyle. Oxidative stress is one the most important …

Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

Nonalcoholic fatty liver disease (NAFLD) is common in the elderly, in whom it carries a more
substantial burden of hepatic (nonalcoholic steatohepatitis, cirrhosis and hepatocellular …

The prevalence of diabetes increases with age, driven in part by an absolute increase in
incidence among adults aged 65 years and older. Individuals with diabetes are at higher risk …

The activity of chaperone-mediated autophagy (CMA), a catabolic pathway for selective
degradation of cytosolic proteins in lysosomes, decreases with age, but the consequences …

The liver is the only internal human organ capable of natural regeneration of lost tissue, as
little as 25% of a liver can regenerate into a whole liver. The process of aging predisposes to …

Insulin resistance (IR) underlines aging and aging-associated medical (diabetes, obesity,
dyslipidemia, hypertension) and psychiatric (depression, cognitive decline) disorders …