RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that
influences a wide array of biological processes in mesenchymal stem cells (MSCs). These …

Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and
elderly people. However, current treatment for OA in its early stages is ineffective, and drug …

Osteoblast apoptosis is a prominent factor for disrupting skeletal homeostasis in multiple
inflammatory bone diseases. METTL3, a key methyltransferase that catalyzes the N6 …

Excessive differentiation of osteoclasts contributes to the disruption of bone homeostasis in
inflammatory bone diseases. Methyltransferase-like 3 (METTL3), the core methyltransferase …

Background Diabetes mellitus (DM) and periodontitis are two prevalent diseases with
mutual influence. Accumulation of advanced glycation end products (AGEs) in …

Emerging evidence has suggested that N 6‑methyladenosine (m6A) modification, a typical
RNA methylation modification, controls the fate of modified transcripts and is involved in the …

Long noncoding RNAs (lncRNAs) play critical roles in tumor progression regulation,
including osteosarcoma. Evidence indicates that N6-methyladenosine (m6A) modification …

Diffuse large B‐cell lymphoma (DLBCL) is the most common lymphoid subtype. However,
unsatisfactory survival outcomes remain a major challenge, and the underlying mechanisms …

Background Osteoarthritis (OA) is a degenerative joint disease with lacking effective
prevention targets. A disintegrin and metalloproteinase with thrombospondin motifs 12 …

Abstract N6-methyladenosine (m 6 A), the most prevalent internal modification in mRNA, is
related to the pathogenesis of osteoporosis (OP). Although methyltransferase Like-3 …