Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation.
Recent findings identified independent clinical clusters in Behçet's disease, each involving …

The ocular tissue microenvironment is immune privileged and uses several mechanisms of
immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier …

Dysregulation of CD4+ T cell differentiation is linked to autoimmune diseases. Metabolic
reprogramming from oxidative phosphorylation to glycolysis and accumulation of lactate are …

Uveitis is a generic term for inflammation of the uvea, which includes the iris, ciliary body,
and choroid. Prevalence of underlying non-infectious uveitis varies by race and region and …

Ammonia nitrogen is extremely toxic to aquatic animals, and is also the most common
pollutant in the aquatic environment. In order to investigate the effect of high concentration of …

Interleukin-17 (IL-17) family cytokines are potent drivers of inflammatory responses.
Although IL-17 was originally identified as a cytokine that induces protective effects against …

Behcet's syndrome (BS) is a chronic systemic inflammatory vasculitis with a wide range of
clinical manifestations including recurrent oral and genital ulcers; cutaneous lesions; and …

Dendritic cells (DCs) are the major antigen-presenting cells and play an important role in
autoimmune uveitis. Emerging evidence suggests that bile acids (BAs) regulate DCs …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Plasmacytoid dendritic cells (pDCs) are a unique subpopulation of immune cells, distinct
from classical dendritic cells. pDCs are generated in the bone marrow and following …