The loss of functional response upon continuous or repeated exposure to agonist,
desensitization, is an intriguing phenomenon if not as yet a well‐defined physiological …

α7 neuronal nicotinic acetylcholine receptors (nAChRs) constitute one of the predominant
nAChR subtypes in the mammalian brain. Within the ventral tegmental area (VTA), nicotine …

Impairment in cholinergic systems is a highly consistent finding in human dementia. Among
cholinergic markers, marked decreases in nicotine binding have been most consistently …

Neural crest cells (NCCs) are vertebrate stem cells that give rise to various cell types
throughout the developing body in early life. Here, we utilized single-cell transcriptomic …

Atropine, a classical muscarinic antagonist, has been reported previously to inhibit neuronal
nicotinic acetylcholine receptors (nAChRs). In the present study, the action of atropine has …

Myasthenia gravis (MG), a prototypic antibody-mediated autoimmune disease, presents an
excellent target for scientific research aimed at a better understanding of the disease itself …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized
clinically by cognitive decline and memory loss. Caffeine and nicotine are the most …

Septal innervation of basal forebrain cholinergic neurons to the hippocampus is critical for
normal learning and memory and is severely degenerated in Alzheimer's disease. To …

The minimal promoter of the human α 3 nicotinic receptor subunit gene has been mapped to
a region of 60 base pairs and found to contain two Sp1 sites, one of which is essential for …

Alterations in nicotinic acetylcholine (nAChR) receptor number can be induced by chronic
exposure to nicotine possibly by stabilization of the desensitized state (s) of the receptor …