Particulate vaccines: on the quest for optimal delivery and immune response

ML De Temmerman, J Rejman, J Demeester… - Drug discovery today, 2011 - Elsevier
Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their
immunogenicity is impaired. This hurdle might be overcome by the use of micro-and …

Biodegradable poly (lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens

W Jiang, RK Gupta, MC Deshpande… - Advanced drug delivery …, 2005 - Elsevier
Injectable biodegradable polymeric particles (usually microspheres) represent an exciting
approach to control the release of vaccine antigens to reduce the number of doses in the …

[图书][B] Handbook of encapsulation and controlled release

M Mishra - 2015 - books.google.com
The field of encapsulation, especially microencapsulation, is a rapidly growing area of
research and product development. The Handbook of Encapsulation and Controlled …

Particulate formulations for the delivery of poly (I: C) as vaccine adjuvant

AM Hafner, B Corthésy, HP Merkle - Advanced drug delivery reviews, 2013 - Elsevier
Current research and development of antigens for vaccination often center on purified
recombinant proteins, viral subunits, synthetic oligopeptides or oligosaccharides, most of …

Vaccine adjuvants: current challenges and future approaches

JH Wilson-Welder, MP Torres, MJ Kipper… - Journal of …, 2009 - Elsevier
For humans, companion animals, and food producing animals, vaccination has been touted
as the most successful medical intervention for the prevention of disease in the twentieth …

Micro and nanoparticle‐based delivery systems for vaccine immunotherapy: an immunological and materials perspective

J Leleux, K Roy - Advanced healthcare materials, 2013 - Wiley Online Library
The development and widespread application of vaccines has been one of the most
significant achievements of modern medicine. Vaccines have not only been instrumental in …

Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response

V Kanchan, AK Panda - Biomaterials, 2007 - Elsevier
Size of the polymeric particulate antigen delivery system and its interactions with antigen-
presenting cells (APCs) influence the immune response both qualitatively and quantitatively …

Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination

PC DeMuth, WF Garcia‐Beltran… - Advanced functional …, 2013 - Wiley Online Library
Transcutaneous administration has the potential to improve therapeutics delivery, providing
an approach that is safer and more convenient than traditional alternatives, while offering …

[HTML][HTML] Harnessing dendritic cells for poly (D, L-lactide-co-glycolide) microspheres (PLGA MS)—Mediated anti-tumor therapy

J Koerner, D Horvath, M Groettrup - Frontiers in immunology, 2019 - frontiersin.org
With emerging success in fighting off cancer, chronic infections, and autoimmune diseases,
immunotherapy has become a promising therapeutic approach compared to conventional …

Single-injection vaccines: Progress, challenges, and opportunities

KJ McHugh, R Guarecuco, R Langer… - Journal of Controlled …, 2015 - Elsevier
Currently, vaccination is the most efficient and cost-effective medical treatment for infectious
diseases; however, each year 10 million infants remain underimmunized due to current …