The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …

The receptors of the innate immune system detect specific microbial ligands to promote
effective inflammatory and adaptive immune responses. Although this idea is well …

Nucleotide‐binding oligomerization domain (NOD) and leucine‐rich repeat (LRR)‐
containing receptors or NOD‐like receptors (NLRs) are cytosolic pattern recognition …

Inflammasomes are multiprotein complexes that drive inflammation and contribute to
protective immunity against pathogens and immune pathology in autoinflammatory …

Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …

The prototypical model for NOD-like receptor (NLR) inflammasome assembly includes
nucleotide-dependent activation of the NLR downstream of pathogen-or danger-associated …

Inflammation has an established role in cancer development and progression and is a key
player in regulating the entry and exit of immune cells in the tumor microenvironment …

Inflammasomes are cytoplasmic sensors that regulate the activity of caspase-1 and the
secretion of interleukin-1β (IL-1β) or interleukin-18 (IL-18) in response to foreign molecules …

Tuberculosis is a serious public health problem aggravated by the slow progress in the
development of new anti-tuberculosis drugs. The hyper-reactive TB patients have suffered …

Mycobacterium tuberculosis infection causes high rates of morbidity and mortality. Host-
directed therapy may enhance the immune response, reduce tissue damage and shorten …