Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Metabolism reprogramming is critical for both cancer progression and effective immune
responses in the tumor microenvironment. Amino acid metabolism in different cells and their …

Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours,,–, but the
cause of this link is unknown. Here we show that tumour cells disrupt methionine …

Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …

The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …

The microorganisms that live symbiotically in human beings are increasingly recognized as
important players in health and disease. The largest collection of these microorganisms is …

Globally breast cancer is the leading cause of cancer death among women. The breast
consists of epithelium, stroma and a mucosal immune system that make up a complex …

Background Obesity develops due to an imbalance in energy homeostasis, wherein energy
intake exceeds energy expenditure. Accumulating evidence shows that manipulations of …

The concept that dietary changes could improve the response to cancer therapy is extremely
attractive to many patients, who are highly motivated to take control of at least some aspect …

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …