How hormonal contraceptives shape brain and behavior: A review of preclinical studies

A Concas, M Serra, P Porcu - Frontiers in neuroendocrinology, 2022 - Elsevier
Steroid hormones influence different aspects of brain function, including development,
neurogenesis, neuronal excitability, and plasticity, thus affecting emotional states, cognition …

Spectral dynamic causal modelling in healthy women reveals brain connectivity changes along the menstrual cycle

E Hidalgo-Lopez, P Zeidman, TA Harris, A Razi… - Communications …, 2021 - nature.com
Longitudinal menstrual cycle studies allow to investigate the effects of ovarian hormones on
brain organization. Here, we use spectral dynamic causal modelling (spDCM) in a triple …

Subcortical structural changes along the menstrual cycle: beyond the hippocampus

B Pletzer, TA Harris, E Hidalgo-Lopez - Scientific reports, 2018 - nature.com
Animal studies have robustly shown hormone related changes in spine density in various
brain areas, specifically the hippocampus. Literature on hormone dependent gray matter …

Hormonal contraceptive use is associated with neural and affective changes in healthy young women

N Lisofsky, M Riediger, J Gallinat, U Lindenberger… - Neuroimage, 2016 - Elsevier
Previous neuroimaging research has demonstrated that female gonadal hormones can alter
the structure and function of adult women's brains. So far, we do not know how hormonal …

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group

J Leerssen, TF Blanken, E Pozzi, N Jahanshad… - Translational …, 2020 - nature.com
It has been difficult to find robust brain structural correlates of the overall severity of major
depressive disorder (MDD). We hypothesized that specific symptoms may better reveal …

Hormonal cycles, brain network connectivity, and windows of vulnerability to affective disorder

JM Andreano, A Touroutoglou, B Dickerson… - Trends in …, 2018 - cell.com
The rate of affective disorder is substantially higher in women than in men, and considerable
evidence points to the actions of ovarian hormones in mediating this disparity. In this …

What is there to know about the effects of progestins on the human brain and cognition?

R Griksiene, R Monciunskaite, O Ruksenas - Frontiers in …, 2022 - Elsevier
Progestins are an important component of hormonal contraceptives (HCs) and hormone
replacement therapies (HRTs). Despite an increasing number of studies elucidating the …

Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal …

M Woelfer, M Li, L Colic, T Liebe, X Di… - The World Journal of …, 2020 - Taylor & Francis
Objectives Synaptic plasticity and brain-derived neurotrophic factor (BDNF) signalling are
proposed to play key roles in antidepressant drug action. Ketamine, an N-methyl-D …

Previous contraceptive treatment relates to grey matter volumes in the hippocampus and basal ganglia

B Pletzer, TA Harris, E Hidalgo-Lopez - Scientific reports, 2019 - nature.com
Oral contraceptive (OC) effects on the brain have gained increasing interest, but are highly
controversial. Previous studies suggest that OC users have larger hippocampi …

Modeling hormonal contraception in female rats: A framework for studies in behavioral neurobiology

JM Lacasse, E Gomez-Perales, WG Brake - Frontiers in …, 2022 - Elsevier
Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so
is our understanding of the impact of HC on the brain and behavior. Here, we provide a …