Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
D Hernan Perez de la Ossa, M Lorente, ME Gil-Alegre… - PLoS …, 2013 - journals.plos.org
Cannabinoids, the active components of marijuana and their derivatives, are currently
investigated due to their potential therapeutic application for the management of many …
investigated due to their potential therapeutic application for the management of many …
Is autophagy inhibition in combination with temozolomide a therapeutically viable strategy?
AM Elshazly, DA Gewirtz - Cells, 2023 - mdpi.com
Temozolomide is an oral alkylating agent that is used as the first line treatment for
glioblastoma multiform, and in recurrent anaplastic astrocytoma, as well as having …
glioblastoma multiform, and in recurrent anaplastic astrocytoma, as well as having …
A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
CY Lee, SP Wey, MH Liao, WL Hsu, HY Wu… - International …, 2008 - Elsevier
It has been shown that leukemia and glioma cells are sensitive to cannabidiol (CBD)-
induced apoptosis, whereas primary monocytes and glia cells are relatively insensitive. In …
induced apoptosis, whereas primary monocytes and glia cells are relatively insensitive. In …
A dual receptor targeting and blood–brain barrier penetrating co-drug-loaded particle mediating inhibition of oxidative phosphorylation for targeted therapy of …
Y Sun, J Kong, X Ge, M Mao, H Yu, J Liu… - Chemical Engineering …, 2023 - Elsevier
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Effective
treatment for GBM is limited by the presence of the blood–brain barrier (BBB) and low …
treatment for GBM is limited by the presence of the blood–brain barrier (BBB) and low …
Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment
Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we
have minimal control over its reoccurrence and resistance to current pharmacotherapies …
have minimal control over its reoccurrence and resistance to current pharmacotherapies …
Cannabinoids modulate neuronal activity and cancer by CB1 and CB2 receptor-independent mechanisms
K Soderstrom, E Soliman, R Van Dross - Frontiers in Pharmacology, 2017 - frontiersin.org
Cannabinoids include the active constituents of Cannabis or are molecules that mimic the
structure and/or function of these Cannabis-derived molecules. Cannabinoids produce …
structure and/or function of these Cannabis-derived molecules. Cannabinoids produce …
Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma
M Kusaczuk, ET Ambel, M Naumowicz… - Biochimica et Biophysica …, 2023 - Elsevier
Despite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM)
remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the …
remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the …
Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8
We recently reported that cannabidiol (CBD) exhibited a generalized suppressive effect on T-
cell functional activities in splenocytes directly exposed to CBD in vitro or isolated from CBD …
cell functional activities in splenocytes directly exposed to CBD in vitro or isolated from CBD …
RETRACTED ARTICLE: Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures
Radiotherapy combined with chemotherapy is the major treatment modality for human
glioblastoma multiforme (GBM). GBMs eventually relapse after treatment and the average …
glioblastoma multiforme (GBM). GBMs eventually relapse after treatment and the average …
Assessment of cannabidiol and Δ9-tetrahydrocannabiol in mouse models of medulloblastoma and ependymoma
C Andradas, J Byrne, M Kuchibhotla, M Ancliffe… - Cancers, 2021 - mdpi.com
Simple Summary Phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol
(CBD) have been demonstrated to exhibit anti-cancer activity in preclinical models of brain …
(CBD) have been demonstrated to exhibit anti-cancer activity in preclinical models of brain …