Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme

D Hernan Perez de la Ossa, M Lorente, ME Gil-Alegre… - PLoS …, 2013 - journals.plos.org
Cannabinoids, the active components of marijuana and their derivatives, are currently
investigated due to their potential therapeutic application for the management of many …

Is autophagy inhibition in combination with temozolomide a therapeutically viable strategy?

AM Elshazly, DA Gewirtz - Cells, 2023 - mdpi.com
Temozolomide is an oral alkylating agent that is used as the first line treatment for
glioblastoma multiform, and in recurrent anaplastic astrocytoma, as well as having …

A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells

CY Lee, SP Wey, MH Liao, WL Hsu, HY Wu… - International …, 2008 - Elsevier
It has been shown that leukemia and glioma cells are sensitive to cannabidiol (CBD)-
induced apoptosis, whereas primary monocytes and glia cells are relatively insensitive. In …

A dual receptor targeting and blood–brain barrier penetrating co-drug-loaded particle mediating inhibition of oxidative phosphorylation for targeted therapy of …

Y Sun, J Kong, X Ge, M Mao, H Yu, J Liu… - Chemical Engineering …, 2023 - Elsevier
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Effective
treatment for GBM is limited by the presence of the blood–brain barrier (BBB) and low …

Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment

A Bachari, N Nassar, E Schanknecht… - WIREs Mechanisms …, 2024 - Wiley Online Library
Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we
have minimal control over its reoccurrence and resistance to current pharmacotherapies …

Cannabinoids modulate neuronal activity and cancer by CB1 and CB2 receptor-independent mechanisms

K Soderstrom, E Soliman, R Van Dross - Frontiers in Pharmacology, 2017 - frontiersin.org
Cannabinoids include the active constituents of Cannabis or are molecules that mimic the
structure and/or function of these Cannabis-derived molecules. Cannabinoids produce …

Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma

M Kusaczuk, ET Ambel, M Naumowicz… - Biochimica et Biophysica …, 2023 - Elsevier
Despite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM)
remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the …

Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8

HY Wu, RM Chu, CC Wang, CY Lee, SH Lin… - Toxicology and applied …, 2008 - Elsevier
We recently reported that cannabidiol (CBD) exhibited a generalized suppressive effect on T-
cell functional activities in splenocytes directly exposed to CBD in vitro or isolated from CBD …

RETRACTED ARTICLE: Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures

VN Ivanov, PW Grabham, CC Wu, TK Hei - Scientific reports, 2020 - nature.com
Radiotherapy combined with chemotherapy is the major treatment modality for human
glioblastoma multiforme (GBM). GBMs eventually relapse after treatment and the average …

Assessment of cannabidiol and Δ9-tetrahydrocannabiol in mouse models of medulloblastoma and ependymoma

C Andradas, J Byrne, M Kuchibhotla, M Ancliffe… - Cancers, 2021 - mdpi.com
Simple Summary Phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol
(CBD) have been demonstrated to exhibit anti-cancer activity in preclinical models of brain …