Involvement of metabolic lipid mediators in the regulation of apoptosis

P Wójcik, N Žarković, A Gęgotek, E Skrzydlewska - Biomolecules, 2020 - mdpi.com
Apoptosis is the physiological mechanism of cell death and can be modulated by
endogenous and exogenous factors, including stress and metabolic alterations. Reactive …

Cannabinoid cancer biology and prevention

SD McAllister, ME Abood, J Califano… - JNCI …, 2021 - academic.oup.com
Plant-based, synthetic, and endogenous cannabinoids have been shown to control a
diverse array of biological processes, including regulation of cell fate across cancers. Their …

Cannabidiol on the Path from the Lab to the Cancer Patient: Opportunities and Challenges

M Olivas-Aguirre, L Torres-López, K Villatoro-Gómez… - Pharmaceuticals, 2022 - mdpi.com
Cannabidiol (CBD), a major non-psychotropic component of cannabis, is receiving growing
attention as a potential anticancer agent. CBD suppresses the development of cancer in …

Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells

Y Li, Q Wu, X Li, P Cournoyer, S Choudhuri, L Guo… - Archives of …, 2024 - Springer
Cannabidiol (CBD), one of the major components extracted from the plant Cannabis sativa
L., has been used as a prescription drug to treat seizures in many countries. CBD-induced …

Repurposing cannabidiol as a potential drug candidate for anti-tumor therapies

F Wang, G Multhoff - Biomolecules, 2021 - mdpi.com
In recent years, evidence has accumulated that cannabinoids—especially the non-
psychoactive compound, cannabidiol (CBD)—possess promising medical and …

Cannabidiol as a promising therapeutic option in IC/BPS: in vitro evaluation of its protective effects against inflammation and oxidative stress

T Kuret, ME Kreft, R Romih, P Veranič - International Journal of Molecular …, 2023 - mdpi.com
Several animal studies have described the potential effect of cannabidiol (CBD) in
alleviating the symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic …

Advances and challenges in modeling cannabidiol pharmacokinetics and hepatotoxicity

JL Beers, Z Zhou, KD Jackson - Drug Metabolism and Disposition, 2024 - ASPET
Cannabidiol (CBD) is a pharmacologically active metabolite of cannabis that is US Food and
Drug Administration approved to treat seizures associated with Lennox-Gastaut syndrome …

[HTML][HTML] The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspects

F Hosami, MH Ghadimkhah, V Salimi… - Biomedicine & …, 2021 - Elsevier
Cancer, as a mysterious and complex disease, has a multi-stage molecular process that
uses the cellular molecular machine and multiple signaling pathways to its advantage …

[HTML][HTML] Cannabinoid-associated cell death mechanisms in tumor models

G Calvaruso, O Pellerito… - … journal of oncology, 2012 - spandidos-publications.com
In recent years, cannabinoids (the active components of Cannabis sativa) and their
derivatives have received considerable interest due to findings that they can affect the …

Cannabidiol effects on behaviour and immune gene expression in zebrafish (Danio rerio)

HM Jensen, R Korbut, PW Kania, K Buchmann - PloS one, 2018 - journals.plos.org
Various preparations and extracts of the plant Cannabis sativa (family cannabaceae) are
used as herbal medicinal drugs against a series of disorders but the plant contains a wide …