Regulation of heat shock transcription factors and their roles in physiology and disease
R Gomez-Pastor, ET Burchfiel, DJ Thiele - Nature reviews Molecular …, 2018 - nature.com
The heat shock transcription factors (HSFs) were discovered over 30 years ago as direct
transcriptional activators of genes regulated by thermal stress, encoding heat shock …
transcriptional activators of genes regulated by thermal stress, encoding heat shock …
[HTML][HTML] Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms
Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is
produced chiefly by the liver and kidney. It presents in different organs, including retina …
produced chiefly by the liver and kidney. It presents in different organs, including retina …
[HTML][HTML] Astrocytes and microglia as non-cell autonomous players in the pathogenesis of ALS
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that leads
to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by …
to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by …
Autophagy in neuroinflammatory diseases
S Muller, S Brun, F René, J de Sèze, JP Loeffler… - Autoimmunity …, 2017 - Elsevier
Autophagy is a metabolically-central process that is crucial in diverse areas of cell
physiology. It ensures a fair balance between life and death molecular and cellular flows …
physiology. It ensures a fair balance between life and death molecular and cellular flows …
Expedition into taurine biology: structural insights and therapeutic perspective of taurine in neurodegenerative diseases
Neurodegenerative diseases (NDs) are characterized by the accumulation of misfolded
proteins. The hallmarks of protein aggregation in NDs proceed with impairment in the …
proteins. The hallmarks of protein aggregation in NDs proceed with impairment in the …
Thermal history and gape of individual Mytilus californianus correlate with oxidative damage and thermoprotective osmolytes
The ability of animals to cope with environmental stress depends–in part–on past
experience, yet knowledge of the factors influencing an individual's physiology in nature …
experience, yet knowledge of the factors influencing an individual's physiology in nature …
L-Citrulline level and transporter activity are altered in experimental models of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease caused by the
death of the neurons regulating the voluntary muscles which leads to the progressive …
death of the neurons regulating the voluntary muscles which leads to the progressive …
Morphometric and neurochemical alterations found in l-BMAA treated rats
E de Munck, E Muñoz-Sáez, BG Miguel… - Environmental …, 2015 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive muscle paralysis that reflects the motoneurons' degeneration. Several studies …
progressive muscle paralysis that reflects the motoneurons' degeneration. Several studies …
Transport alteration of 4-phenyl butyric acid mediated by a sodium-and proton-coupled monocarboxylic acid transporter system in ALS model cell lines (NSC-34) …
Phenyl butyric acid (PBA) has histone deacetylase inhibitory and neuroprotective effects. We
aimed to examine the transport alteration activity of PBA in control (WT) and disease (MT) …
aimed to examine the transport alteration activity of PBA in control (WT) and disease (MT) …
HSF1 and its role in Huntington's disease pathology
H Kim, R Gomez-Pastor - Cell Biology and Translational Medicine, Volume …, 2022 - Springer
Purpose of review: Heat shock factor 1 (HSF1) is the master transcriptional regulator of the
heat shock response (HSR) in mammalian cells and is a critical element in maintaining …
heat shock response (HSR) in mammalian cells and is a critical element in maintaining …